dc.contributor.author | Kallmes, D. F. | |
dc.contributor.author | Hanel, R. | |
dc.contributor.author | Lopes, D. | |
dc.contributor.author | Boccardi, E. | |
dc.contributor.author | Bonafe, A. | |
dc.contributor.author | Cekirge, S. | |
dc.contributor.author | Fiorella, D. | |
dc.contributor.author | Jabbour, P. | |
dc.contributor.author | Levy, E. | |
dc.contributor.author | McDougall, C. | |
dc.contributor.author | Siddiqui, A. | |
dc.contributor.author | Szikora, I. | |
dc.contributor.author | Woo, H. | |
dc.contributor.author | Albuquerque, F. | |
dc.contributor.author | Bozorgchami, H. | |
dc.contributor.author | Dashti, S. R. | |
dc.contributor.author | Almandoz, J. E. Delgado | |
dc.contributor.author | Kelly, M. E. | |
dc.contributor.author | Turner, R. | |
dc.contributor.author | Woodward, B. K. | |
dc.contributor.author | Brinjikji, W. | |
dc.contributor.author | Lanzino, G. | |
dc.contributor.author | Lylyk, P. | |
dc.date.accessioned | 2019-12-10T11:31:35Z | |
dc.date.available | 2019-12-10T11:31:35Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0195-6108 | |
dc.identifier.uri | https://doi.org/10.3174/ajnr.A4111 | |
dc.identifier.uri | http://hdl.handle.net/11655/15928 | |
dc.description.abstract | BACKGROUND AND PURPOSE: Flow diverters are increasingly used in the endovascular treatment of intracranial aneurysms. Our aim was to determine neurologic complication rates following Pipeline Embolization Device placement for intracranial aneurysm treatment in a real-world setting. MATERIALS AND METHODS: We retrospectively evaluated all patients with intracranial aneurysms treated with the Pipeline Embolization Device between July 2008 and February 2013 in 17 centers worldwide. We defined 4 subgroups: internal carotid artery aneurysms of >= 10 mm mm, ICA aneurysms of <10 mm, other anterior circulation aneurysms, and posterior circulation aneurysms. Neurologic complications included spontaneous rupture, intracranial hemorrhage, ischemic stroke, permanent cranial neuropathy, and mortality. Comparisons were made with t tests or ANOVAs for continuous variables and the Pearson chi(2) or Fisher exact test for categoric variables. RESULTS: In total, 793 patients with 906 aneurysms were included. The neurologic morbidity and mortality rate was 8.4% (67/793), highest in the posterior circulation group (16.4%, 9/55) and lowest in the ICA <10-mm group (4.8%,14/294) (P = .01). The spontaneous rupture rate was 0.6% (5/793). The intracranial hemorrhage rate was 2.4% (19/793). Ischemic stroke rates were 4.7% (37/793), highest in patients with posterior circulation aneurysms (7.3%, 4/55) and lowest in the ICA <10-mm group (2.7%, 8/294) (P = .16). Neurologic mortality was 3.8% (30/793), highest in the posterior circulation group (10.9%, 6/55) and lowest in the anterior circulation ICA <10-mm group (1.4%, 4/294) (P < .01). CONCLUSIONS: Aneurysm treatment with the Pipeline Embolization Device is associated with the lowest complication rates when used to treat small ICA aneurysms. Procedure-related morbidity and mortality are higher in the treatment of posterior circulation and giant aneurysms. | |
dc.language.iso | en | |
dc.publisher | Amer Soc Neuroradiology | |
dc.relation.isversionof | 10.3174/ajnr.A4111 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Neurosciences & Neurology | |
dc.subject | Radiology, Nuclear Medicine & Medical Imaging | |
dc.title | International Retrospective Study of the Pipeline Embolization Device: A Multicenter Aneurysm Treatment Study | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | American Journal Of Neuroradiology | |
dc.contributor.department | Radyoloji | |
dc.identifier.volume | 36 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 108 | |
dc.identifier.endpage | 115 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |