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dc.contributor.authorMuehlschlegel, Susanne
dc.contributor.authorKursun, Oğuzhan
dc.contributor.authorTopçuoğlu, Mehmet A.
dc.contributor.authorFok, Joshua
dc.contributor.authorSinghal, Aneesh B.
dc.date.accessioned2019-12-10T11:24:47Z
dc.date.available2019-12-10T11:24:47Z
dc.date.issued2013
dc.identifier.issn2168-6149
dc.identifier.urihttps://doi.org/10.1001/jamaneurol.2013.3484
dc.identifier.urihttp://hdl.handle.net/11655/15668
dc.description.abstractIMPORTANCE Reversible cerebral vasoconstriction syndrome (RCVS) is a clinical-angiographic syndrome characterized by recurrent thunderclap headaches and reversible segmental multifocal cerebral artery narrowing. More than 30% of patients with RCVS develop subarachnoid hemorrhage (SAH). Patients with RCVS with SAH (RCVS-SAH) are often misdiagnosed as having potentially ominous conditions such as aneurysmal SAH (aSAH) or cryptogenic "angiogram-negative" SAH (cSAH) owing to overlapping clinical and imaging features. OBJECTIVE To identify predictors that can distinguish RCVS-SAH from aSAH and cSAH at the time of clinical presentation. DESIGN Retrospective analysis of 3 patient cohorts: patients with RCVS (1998-2009), patients with aSAH (1995-2003), and patients with cSAH (1995-2003). SETTING Academic hospital and tertiary referral center. PARTICIPANTS Consecutive patients with RCVS-SAH (n = 38), aSAH (n = 515), or cSAH (n = 93) whose conditions were diagnosed using standard criteria. MAIN OUTCOMES AND MEASURES Multivariate logistic regression analysis was used to identify predictors that differentiate RCVS-SAH from aSAH and cSAH. RESULTS Predictors differentiating RCVS-SAH from aSAH were younger age, chronic headache disorder, prior depression, prior chronic obstructive pulmonary disease, lower Hunt-Hess grade, lower Fisher SAH group, higher number of affected arteries, and the presence of bilateral arterial narrowing. Predictors differentiating RCVS-SAH from cSAH were younger age, female sex, prior hypertension, chronic headache disorder, lower Hunt-Hess grade, lower Fisher SAH group, and the presence of bilateral arterial narrowing. CONCLUSION AND RELEVANCE We identified important clinical and imaging differences between RCVS-SAH, aSAH, and cSAH that may be useful for improving diagnostic accuracy, clinical management, and resource utilization.
dc.language.isoen
dc.publisherAmer Medical Assoc
dc.relation.isversionof10.1001/jamaneurol.2013.3484
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & Neurology
dc.titleDifferentiating Reversible Cerebral Vasoconstriction Syndrome With Subarachnoid Hemorrhage From Other Causes Of Subarachnoid Hemorrhage
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJama Neurology
dc.contributor.departmentNöroloji
dc.identifier.volume70
dc.identifier.issue10
dc.identifier.startpage1254
dc.identifier.endpage1260
dc.description.indexWoS
dc.description.indexScopus


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