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dc.contributor.authorCarmeli, Y.
dc.contributor.authorAkova, M.
dc.contributor.authorCornaglia, G.
dc.contributor.authorDaikos, G. L.
dc.contributor.authorGarau, J.
dc.contributor.authorHarbarth, S.
dc.contributor.authorRossolini, G. M.
dc.contributor.authorSouli, M.
dc.contributor.authorGiamarellou, H.
dc.date.accessioned2019-12-10T11:11:22Z
dc.date.available2019-12-10T11:11:22Z
dc.date.issued2010
dc.identifier.issn1198-743X
dc.identifier.urihttps://doi.org/10.1111/j.1469-0691.2009.03115.x
dc.identifier.urihttp://hdl.handle.net/11655/14962
dc.description.abstractAlthough the rapid spread of carbapenemase-producing Gram-negatives (CPGNs) is providing the scientific community with a great deal of information about the molecular epidemiology of these enzymes and their genetic background, data on how to treat multidrug-resistant or extended drug-resistant carbapenemase-producing Enterobacteriaceae and how to contain their spread are still surprisingly limited, in spite of the rapidly increasing prevalence of these organisms and of their isolation from patients suffering from life-threatening infections. Limited clinical experience and several in vitro synergy studies seem to support the view that antibiotic combinations should be preferred to monotherapies. But, in light of the data available to date, it is currently impossible to quantify the real advantage of drug combinations in the treatment of these infections. Comprehensive clinical studies of the main therapeutic options, broken down by pathogen, enzyme and clinical syndrome, are definitely lacking and, as carbapenemases keep spreading, are urgently needed. This spread is unveiling the substantial unpreparedness of European public health structures to face this worrisome emergency, although experiences from different countries-chiefly Greece and Israel-have shown that CPGN transmission and cross-infection can cause a substantial threat to the healthcare system. This unpreparedness also affects the treatment of individual patients and infection control policies, with dramatic scarcities of both therapeutic options and infection control measures. Although correct implementation of such measures is presumably cumbersome and expensive, the huge clinical and public health problems related to CPGN transmission, alongside the current scarcity of therapeutic options, seem to fully justify this choice.
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.isversionof10.1111/j.1469-0691.2009.03115.x
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInfectious Diseases
dc.subjectMicrobiology
dc.titleControlling The Spread Of Carbapenemase-Producing Gram-Negatives: Therapeutic Approach And Infection Control
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/conferenceObject
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalClinical Microbiology And Infection
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume16
dc.identifier.issue2
dc.identifier.startpage102
dc.identifier.endpage111
dc.description.indexWoS
dc.description.indexScopus


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