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dc.contributor.authorIbanez, Lourdes
dc.contributor.authorOberfield, Sharon E.
dc.contributor.authorWitchel, Selma F.
dc.contributor.authorAuchus, Richard J.
dc.contributor.authorChang, R. Jeffrey
dc.contributor.authorCodner, Ethel
dc.contributor.authorDabadghao, Preeti
dc.contributor.authorDarendeliler, Feyza
dc.contributor.authorElbarbary, Nancy Samir
dc.contributor.authorGambineri, Alessandra
dc.contributor.authorRudaz, Cecilia Garcia
dc.contributor.authorHoeger, Kathleen M.
dc.contributor.authorLopez-Bermejo, Abel
dc.contributor.authorOng, Ken
dc.contributor.authorPena, Alexia S.
dc.contributor.authorReinehr, Thomas
dc.contributor.authorSantoro, Nicola
dc.contributor.authorTena-Sempere, Manuel
dc.contributor.authorTao, Rachel
dc.contributor.authorYildiz, Bulent O.
dc.contributor.authorAlkhayyat, Haya
dc.contributor.authorDeeb, Asma
dc.contributor.authorJoel, Dipesalema
dc.contributor.authorHorikawa, Reiko
dc.contributor.authorde Zegher, Francis
dc.contributor.authorLee, Peter A.
dc.date.accessioned2019-12-10T11:10:18Z
dc.date.available2019-12-10T11:10:18Z
dc.date.issued2017
dc.identifier.issn1663-2818
dc.identifier.urihttps://doi.org/10.1159/000479371
dc.identifier.urihttp://hdl.handle.net/11655/14832
dc.description.abstractThis paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)(1). The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Mullerian hormone, hyper-insulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne, and menstrual irregularities 2 years beyond menarche, and elevated androgen levels. Polycystic ovarian morphology on ultrasound without hyperandrogenism or menstrual irregularities should not be used to diagnose adolescent PCOS. Hyperinsulinemia, insulin resistance, and obesity may be present in adolescents with PCOS, but are not considered to be diagnostic criteria. Treatment of adolescent PCOS should include lifestyle intervention, local therapies, and medications. Insulin sensitizers like metformin and oral contraceptive pills provide short-term benefits on PCOS symptoms. There are limited data on anti-androgens and combined therapies showing additive/synergistic actions for adolescents. Reproductive aspects and transition should be taken into account when managing adolescents. (C) 2017 S. Karger AG, Basel.
dc.language.isoen
dc.publisherKarger
dc.relation.isversionof10.1159/000479371
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndocrinology & Metabolism
dc.subjectPediatrics
dc.titleAn International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalHormone Research In Paediatrics
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume88
dc.identifier.issue6
dc.identifier.startpage371
dc.identifier.endpage395
dc.description.indexWoS
dc.description.indexScopus


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