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dc.contributor.authorOzdemir, Secil Kepil
dc.contributor.authorErkekol, Ferda Oner
dc.contributor.authorUnal, Derya
dc.contributor.authorBuyukozturk, Suna
dc.contributor.authorGelincik, Asli
dc.contributor.authorDursun, Adile Berna
dc.contributor.authorKarakaya, Gul
dc.contributor.authorBavbek, Sevim
dc.date.accessioned2019-12-10T10:54:43Z
dc.date.available2019-12-10T10:54:43Z
dc.date.issued2016
dc.identifier.issn1018-2438
dc.identifier.urihttps://doi.org/10.1159/000450952
dc.identifier.urihttp://hdl.handle.net/11655/14684
dc.description.abstractBackground: We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective study, we aimed to further evaluate the diagnostic workup procedures and characteristics of the patients with suspected PPI hypersensitivity. Methods: This national multicenter study was conducted as a retrospective chart review of patients with a history of PPI-induced immediate hypersensitivity reaction. A total of 60 patients were included. Results of diagnostic workup procedures (standardized skin-prick, intradermal, and oral-provocation tests with PPIs) and the characteristics of the patients were analyzed. Results: Lansopra-zole was the most commonly suspected drug with 41 patients (68.3%), followed by pantoprazole in 12 patients (20.0%), esomeprazole in 6 (10.0%), rabeprazole in 4 (6.7%), and omeprazole in 1 (1.7%). Anaphylaxis (40 patients, 66.7%) was the most common clinical presentation followed by urticaria (17 patients, 28.3%). Diagnostic skin tests with the culprit PPI were positive in 13/26 patients (50.0%). Diagnostic oral-provocation tests were negative in 6/8 patients; 5 of these 6 patients had skin test results with the culprit PPI, and all were negative. Ten patients had at least 1 cross-reactivity. Extensive cross-reactivity (between > 2 PPIs) was detected in 4 patients. Conclusions: Lansoprazole was the most frequently implicated drug and anaphylaxis was the most frequent manifestation of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible crossreactivity among PPIs; however, a safe, alternative PPI can usually be detected by a thorough drug allergy workup. (C) 2016 S. Karger AG, Basel
dc.language.isoen
dc.publisherKarger
dc.relation.isversionof10.1159/000450952
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergy
dc.subjectImmunology
dc.titleManagement of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalInternational Archives Of Allergy And Immunology
dc.contributor.departmentGöğüs Hastalıkları
dc.identifier.volume171
dc.identifier.issue1
dc.identifier.startpage54
dc.identifier.endpage60
dc.description.indexWoS
dc.description.indexScopus


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