Senil Osteoporozda Vasküler Kalsifikasyonun Bir Göstergesi Olarak Serum Fetuin-A Düzeyleri ve Aortik Kalsifikasyon Skorlamasının İncelenmesi

Abstract

ABSTRACT Özbek Emre, The Evaluation of Aortic Calcification Scores and Serum Fetuin-A Levels As A Predictor of Vascular Calcification In Senile Osteoporosis, Hacettepe University Medical Faculty, Thesis in İnternal Medicine, Ankara 2015. Osteoporosis and cardiovascular diseases are among common diseases seen in geriatric population. There are shared pathophysiological mechanisms between the two diseases. Serum Fetuin-A, which is one of the shared mechanisms and a predictor of cardiovascular diseases, is decreased in both osteoporosis and vascular calcification. Although in the literature, there are some studies about the relationship between osteoporosis and cardiovascular diseases; no study was found about the relationship between senile osteoporosis, vascular calcification, and serum Fetuin-A. This played an important role in designing the study. In this study, 70 patients aged 70 years and over, who were admitted to the geriatric medicine outpatient clinic between 1 June 2014 and 30 September 2014 were included. Twenty three patients had osteoporosis and 47 patients didn’t have osteoporosis. The causes of secondary osteoporosis were excluded. Blood samples for serum biochemistry and serum Fetuin-A were collected from the patients. Every patient underwent DEXA for bone mineral densitometry and 2 sided lumbar graphs. When the groups who had and did not have osteoporosis were evaluated for aortic calcification scores and serum Fetuin-A levels, lower levels of serum Fetuin-A and higher degrees of aortic calcification scores were noted in the group who had osteoporosis; but no statistical difference was found between the two groups. When the patients were grouped as osteoporotic, osteopenic, and normal according to their bone mineral density scores; serum Fetuin-A levels were found to be lowest in the osteoporotic group and highest in the normal bone mineral density group. Although there was no statistically significant difference between the groups, it was important to determine the lowest Fetuin-A levels in the osteoporotic group. Further investigations are needed for highlightening the common pathophysiological mechanisms between osteoporosis and cardiovascular diseases, for generalizing the clinical practice of Fetuin-A as a predictor of senile osteoporosis and cardiovascular diseases. Key Words: senile osteoporosis, cardiovascular diseases, aortic calcification scores, serum Fetuin-A