Dosya Biçimi"TÜBİTAK" Enstitüler için listeleme
Toplam kayıt 52, listelenen: 1-20
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Akut myeloblastik lösemi (aml) hastalığı hücrelerinin aptamer temelli akım sitometrik profillenmesi
(Sağlık Bilimleri Enstitüsü, 2023-02)AKCA O, Aptamer Based Flow Cytometric Profiling in Acute Myeloblastic Leukemia (AML) Disease Cells. Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2023. Aptamers are short, ... -
Allojenik Mezenkimal Kök Hücreler ve Mikroakışkan Sistemle Vücut Dışında Testisteki Spermatogonyal Kök Hücre Mikroçevresinin Devamlılığının Sağlanması
(Sağlık Bilimleri Enstitüsü, 2023)Chemoradiotherapeutics used in childhood cancers result in permenant infertility in half of male patients. Bone marrow derived mesenchymal stem cells (BMMSC) share some of their secretomes and their embryonic origin with ... -
Alt-Birim Protein Antijenlerinin İmmunojenitesini Artırmak Amacıyla Yeni Adjuvant/Taşıyıcı Sistemlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-07-22)Infectious diseases encompass 25% of deaths in the world per year. The most effective approach in preventing deaths is vaccination. However, at present, the availability of vaccines for many infectious diseases is still ... -
Alzheimer Hastalığında serum proteomik analizleri ile yeni biyobelirteçlerin araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024)Current diagnostic criteria set for Alzheimer’s Disease (AD) is not sufficient for accurate prediction of the pathology. The use of CSF and PET biomarkers increase the accuracy of diagnoses but they are limited for widespread ... -
Anjiyogenik Mikroiğnelerin Geliştirilmesi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2024)Angiogenesis plays a crucial role in tissue repair processes, ensuring the continuation of important cellular processes as stem cell differentiation, cell proliferation, and migration during tissue repair. It also plays a ... -
Aoc3’ün İnflamatuar ve Neoplastik Kolon Hastalıklarındaki Rolünün Araştırılması
(Sağlık Bilimleri Enstitüsü, 2024)The AOC3 gene is located on chromosome 17 and encodes the protein AOC3 (VAP-1), which is involved in leukocyte trafficking during inflammation. AOC3 is expressed by many different cell groups such as endothelium, adipocytes, ... -
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ... -
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Comparatıve Analysıs of Myeloıd-Derıved Suppressor Cells From Blood and Spleen in Gastrıc and Pancreatıc Cancer
(Sağlık Bilimleri Enstitüsü, 2022-07-29)Under physiological conditions, development and maturation of the myeloid cells take place in the bone marrow. In case of chronic inflammatory disorders such as cancer, production of chemokines, growth factors, and cytokines ... -
Cyberknife® ve Varian RapidArc® TrilogyTM Cihazında Üç Boyutlu Uzaysal Fraksiyone Grid Terapi Doz Karakteristiklerinin Karşılaştırılması
(Kanser Enstitüsü, 2020-12). Lattice therapy is an innovative method to increase the effectiveness of radiotherapy by delivering a high dose to the target volume irradiated through small spaces in one or more fractions.In this study, we investigated ... -
Deselülerize Miyokard-Elastomer Yamaların Hazırlanması ve In Vitro Performanslarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)Heart failure is the final stage of most cardiovascular diseases, such as myocardial infarction. Unlike other tissues such as bone and skin, heart tissue does not have the ability to regenerate and repair itself. This ... -
Development of Jak1 Sirna Medıated Nanotherapeutıcs for Non-Melanoma Skın Cancer Therapy
(Fen Bilimleri Enstitüsü, 2021-06)Non-melanoma skin cancer is one of the most common cancers with still no effective treatment. Due to the side effects observed after long and high dose treatments and acquired resistance to the chemotherapy drugs, different ... -
Development of Karagöz the Shadow Puppetry in Virtual Reality Environment
(Bilişim Enstitüsü, 2023)In this era of technological advancements, the landscape of entertainment has undergone a transformative shift, leaving behind traditional forms in favor of new ones. While the judgment of whether this change is beneficial ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
EARLY MARRIAGES, AUTONOMY AND AFTERTHOUGHTS: INVESTIGATING MARITAL AGE REGRET THROUGH THE LENS OF CONSENT AMONG THE ROMA COMMUNITY IN TÜRKİYE
(Nüfus Etütleri Enstitüsü, 2024-10-28)This thesis examines the phenomenon of child marriage within the Roma community in Turkey, with a particular focus on the concept of "marital age regret" and the role of autonomy in marital decision-making. This study ... -
Fenilketonüri Hastalığının Erken Teşhisi ve Takibi için Disk Tabanlı Hasta Başı Tanı Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-12)Phenylketonuria (PKU) is an autosomal recessive metabolic disease due to dysfunction of phenylalanine hydroxylase (PAH) enzyme, which converts phenylalanine (Phe) amino acid to tyrosine amino acid. Phe amino acid and ... -
Fonksiyonel Pet Nano Fiberlerin Üretilmesi ve Yara Örtüsü Olarak Kullanmak Üzere Modifiye Edilmiş Pet Fiberlere Protein Kaplı Gümüş Nanoparçacıkların Adsorpsiyonu
(Fen Bilimleri Enstitüsü, 2020)In this study, silver nanoparticles (S-AgNPs) coated with sericin were adsorbed on poly (ethylene terephthalate)-g-poly(hydroxyethylmethacrylate) (PET-g-HEMA) nanofibres and the use of the obtained material as wound dressing ... -
Fotovoltaik Uygulamalar için CZTS (Cu2SnZnS4) İnce Filmlerin Sentezi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2022)Today, thin-film-based photovoltaic (PV) structures attract attention in the search for alternatives to Si-based solar cells. Among the thin films, the Cu2ZnSnS4 (CZTS) compound is the most remarkable with its optical and ... -
Genotip İmpütasyonunun Antik Anadolu İnsan Genomlarında Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024-06-14)Genotype imputation presents a solution to the high amount of missing information in low coverage ancient DNA samples. In this thesis, by using the phasing and imputation tool GLIMPSE, the accuracy of genotype imputation ...
