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Functional Exhaustion Of Cd4(+) T Cells Induced By Co-Stimulatory Signals From Myeloid Leukaemia Cells
(Wiley, 2016)
To cope with immune responses, tumour cells implement elaborate strategies such as adaptive resistance and induction of T-cell exhaustion. T-cell exhaustion has been identified as a state of hyporesponsiveness that arises ...
Neisseria Meningitidis Serogroup X St-5799 (St-22 Complex) In Turkey: A Unique Pediatric Case
(Taylor & Francis Inc, 2018)
Although outbreaks of Neisseria meningitidis serogroup X occured in a couple of African countries, a limited number of serogroup X meningococcal cases were reported in America and Europe as well as Turkey. Additionally, ...
Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels In Patients With Hbeag-Negative Chronic Viral Hepatitis B
(Mary Ann Liebert, Inc, 2017)
Toll-like receptors (TLRs) may play an important role in hepatitis-B pathogenesis. However, serum TLR-2 and TLR-4 levels and their association with serum liver enzymes, hepatitis B virus (HBV) DNA, quantitative HBsAg levels, ...
Differential Roles Of Microglia And Monocytes In The Inflamed Central Nervous System
(Rockefeller Univ Press, 2014)
In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ...
Clinical Features Of Candidiasis In Patients With Inherited Interleukin 12 Receptor Beta 1 Deficiency
(Oxford Univ Press, 2014)
Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin ...
Dali: Defining Antibiotic Levels In Intensive Care Unit Patients: Are Current Beta-Lactam Antibiotic Doses Sufficient For Critically Ill Patients?
(Oxford Univ Press, 2014)
Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether beta-lactam antibiotic dosing in critically ill patients achieves concentrations ...
Empiric Therapy With Carbapenem-Sparing Regimens For Bloodstream Infections Due To Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: Results From The Increment Cohort
(Oxford Univ Press, 2017)
Background. There is little information about the efficacy of active alternative drugs to carbapenems except beta-lactam/beta-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum ...
Epidemiology And Outcome Of Fungemia In A Cancer Cohort Of The Infectious Diseases Group (Idg) Of The European Organization For Research And Treatment Of Cancer (Eortc 65031)
(Oxford Univ Press, 2015)
Background. Anti-cancer treatment and the cancer population have evolved since the last European Organisation for Research and Treatment of Cancer (EORTC) fungemia survey, and there are few recent large epidemiological ...