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Toplam kayıt 58, listelenen: 21-30
Management of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience
(Karger, 2016)
Background: We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective ...
Mutations In Stat3 And Diagnostic Guidelines For Hyper-Ige Syndrome
(Mosby-Elsevier, 2010)
Background: The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by infections of the lung and skin, elevated serum IgE, and involvement of the soft and bony tissues. Recently, HIES has been associated ...
A Novel Mutation in the Interleukin-1 Receptor Antagonist Associated with Intrauterine Disease Onset
(Academic Press Inc Elsevier Science, 2012)
Deficiency of the IL-1 receptor antagonist (DIRA) is a recently described rare autoinflammatory disease, caused by loss of function mutations in IL1RN leading to the unopposed activation of the IL-1 pathway. We describe a ...
Additional Diverse Findings Expand The Clinical Presentation of Dock8 Deficiency
(Springer/Plenum Publishers, 2012)
We describe seven Turkish children with DOCK8 deficiency who have not been previously reported. Three patients presented with typical features of recurrent or severe cutaneous viral infections, atopic dermatitis, and ...
Rasgrp1 Deficiency Causes Immunodeficiency With Impaired Cytoskeletal Dynamics
(Nature Publishing Group, 2016)
RASGRP1 is an important guanine nucleotide exchange factor and activator of the RAS-MAPK pathway following T cell antigen receptor (TCR) signaling. The consequences of RASGRP1 mutations in humans are unknown. In a patient ...
Suppression of B-Cell Activation and Ige, Iga, Igg1 and Igg4 Production by Mammalian Telomeric Oligonucleotides
(Wiley-Blackwell, 2013)
Background The fine balance of immunoglobulins (Ig) E, IgG1, IgG4 and IgA in healthy production is maintained by the interaction of B cells with adaptive and innate immune response. The regulation of toll-like receptors ...
A Phase II, Multicenter, Single-Arm Study to Evaluate the Safety and Efficacy of Deferasirox after Hematopoietic Stem Cell Transplantation in Children with Beta-Thalassemia Major
(Elsevier Science Inc, 2018)
We conducted a prospective, phase II, multicenter, single-arm study to evaluate the efficacy and safety of deferasirox in patients age >2 to <18 years with beta-thalassemia major (TM) who underwent hematopoietic stem cell ...
Pharmacokinetics of Colchicine in Pediatric and Adult Patients with Familial Mediterranean Fever
(Biolife Sas, 2012)
This study sought to determine the appropriate starting dose of colchicine in children aged 2 to 4 years with familial Mediterranean fever (FMF) based on steady-state pharmacokinetics in pediatric patients with FMF >= 2 ...
Right Middle Lobe Atelectasis In Children With Asthma And Prognostic Factors
(Japanese Society Allergology, 2016)
Background: Although right middle lobe (RML)-atelectasis of the lungs is a common complication of asthma, the relevant data is limited. The aim of this study is to define the characteristics of RML atelectasis in asthma ...
The Role Of Cd14 Gene Promoter Polymorphism In Tuberculosis Susceptibility
(Elsevier Taiwan, 2013)
Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between ...