Inflamatuar Barsak Hastalıklarında Serum Beta 2 Mikroglobulin Düzeyinin Hastalık Aktivitesi ile Ilişkisi

Abstract

The inflammatory bowel diseases (IBD) are chronic inflammation of the digestive tract. The mucosa of the colon and small intestine of patients are common lymphoplasmacytoid cell infiltration. The inflammatory markers plays role in this inflammatory reaction such as lymphokines, cytokines and leukotriene. Beta 2 microglobulin (β2M) is a low molecular weight protein (11800 d) mainly released from activated lymphocytes. In the study we examined β2M serum levels in patients suffering from IBD, to assess the extent of the disease and the possible correlation between these serum levels and the activity of IBD. Erytrocyte sedimantation rate (ESR), white blood cell count (WBC) and C-reactive protein (CRP) are known to be good predictors of disease activity in IBD. Serum β2M levels increase in all chronic inflammatory and autoimmune disease. This increase is linked to the severity and extant of inflammation. Overall, 78 IBD patients and 30 healthy controls were enrolled. We examined β2M serum levels in 43 ulcerative colitis (UC) patients, 35 with Crohn’s disease (CD) and 30 control subjects, using an enzymatic method. UC and CD patients were divided into two groups according to disease activity: Active and remission. Subjects were divided into two groups according to extend of disease: Left and pancolitis for UC ; İleitis and ileocolitis for CD. All groups were compared for the mean serum β2M levels. As a result, mean β2M values were significantly higher in UC and CD patients than in healthy controls. Mean β2M values were significantly higher in IBD activity than remission. The difference between groups (UC and CD) in terms of serum β2M levels was statistically insignificant. Serum β2M levels may be used as indicator to demostrate disease activity in patient with İBH.