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Toplam kayıt 69, listelenen: 49-68
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Pankreas Kanseri Hücre Hattında TFAM Ekspresyon Düzeyinin Hücre Fonksiyonları Üzerine Etkisi
(Kanser Enstitüsü, 2022-07-29)Pancreatic cancer is an aggressive malignancy with a poor prognosis. Early diagnosis and application of tumor-specific treatment are very important in pancreatic cancer. Therefore, new biomarkers are needed in the diagnosis ... -
Pankreas Kanserinde MUC1, MUC4, MUC16 Molekülleri ile Treg Hücreleri ve Epitelyal-Mezenkimal Transizyon Arasındaki İlişki
(Kanser Enstitüsü, 2020-08-14)Pancreatic cancer has a poor prognosis due to its increased invasion and metastasis capacity. Transmembrane mucins normally have as their functions to protect the epithelial tissues but their expression level is has been ... -
Pankreas Kanserinde Nectin-2 Ekspresyonu ile Sitotoksik T Hücre Fonksiyonları Arasındaki İlişki
(Kanser Enstitüsü, 2023)Checkpoint inhibitors such as anti-CTLA-4, anti-PD1 and anti-PDL-1 are used in the treatment of various cancers. However, they cannot be used in pancreatic cancer due to the lack of PDL-1 expression. Other checkpoint ... -
Prostat Kanserinde Tlr Agonistlerinin M1, M2 Makrofaj Polarizasyonunda Rolü
(Kanser Enstitüsü, 2019)It is well known that inflammation is effective in the development of prostate cancer. Macrophages in the tumor microenvironment are either anti-inflammatory M2-type that help tumor growth or pro-inflammatory M1-type that ... -
Prostat Ve Akciğer Kanserlerinin Vmat (Volümetrik Ayarlı Radyoterapi) ve Yart (Yoğunluk Ayarlı Radyoterapi) Tabanlı Tedavilerinde Termal Fotonötron Kontaminasyonunun İncelenmesi
(Kanser Enstitüsü, 2022)Yılmaz, E. Investigation of Thermal Photoneutron Contamination in VMAT (Volumetric Modulated Arc Therapy) and IMRT (Intensity-Modulated Radiation Therapy)-Based Treatments of Prostate and Lung Cancers, Hacettepe University ... -
Racial Disparity in Tumor Microenvironment and Outcomes in Residual Breast Cancer after Neoadjuvant Chemotherapy
(Kanser Enstitüsü, 2023-06-12)Black patients with residual estrogen receptor-positive (ER+) breast cancer after neoadjuvant chemotherapy (NAC) have inferior survival compared to white women resulting racial disparity in breast cancer survival. Differences ... -
Reproductive Cancer Risk Factors Among Relatives of Cancer Patients Seeking Treatment in Hacettepe University Oncology Hospital
(Kanser Enstitüsü, 2014)This study is an attempt to measure the frequency of specific gynecological cancer risk factors in female relatives of cancer patients. A cancer risk assessment questionnaire had been designed in the Department of Preventive ... -
Selection and Charaterization of İmmune-Resistant Acute Myeloid Leukemia Cells
(Kanser Enstitüsü, 2024)Resistance to immunity is associated with the selection of cancer cells with superior capacities to survive inflammatory reactions. In the case of AML, immune reactions induce dynamic changes at genetic and epigenetic ... -
Stereotaktik Radyocerrahi ve Stereotaktik Beden Radyoterapisi Uygulamalarında Manyetik Rezonans Görüntüleme Tabanlı Tedavi Planlama Sisteminin Kullanılabilirliği
(Kanser Enstitüsü, 2021-02-05)In this study, feasibility of Magnetic Resonance Imaging (MRI) based treatment planning system instead of computed tomography (CT) in SRC and SBRT was evaluated. Three different scenarios were created for density and ... -
Systemıc Vh4-34-Encoded Antıbody Responses Agaınst Commensal Bacterıa in Patıents Wıth Systemıc Lupus Erythematosus
(Kanser Enstitüsü, 2023-09)The germline immunoglobulin variable heavy chain 4–34 encoding B lymphocytes (known as VH4–34 or 9G4 B cells) are endowed with inherent self-reactivity due to the presence of a germline AVY motif in their framework region ... -
The Effect of Acute Myeloid Leukemia Cells Expressing PD-L2 Co-Stimulatory Molecule on Helper T Cell Activation
(Sağlık Bilimleri Enstitüsü, 2017-07-25)The binding of PD-1 to its ligands (PD-L1 and PD-L2) inhibits and/or regulates T cell responses. Myeloid leukemia cells can express both co-activatory and co-inhibitory molecules simultaneously. The function of PD-L1 in ... -
The Effect of Inducıble Costımulatory Lıgand (Icos-Lg) Expressıng Myeloıd Leukemıa Cells on Helper T Lymphocyte Actıvatıon and Exhaustıon
(Kanser Enstitüsü, 2015)T cell exhaustion is characterized by progressive loss of cytokine production, decreased proliferation and resistance to reactivation especially upon continuous antigen stimulation. Despite being potent stimulators of ... -
The Effects of Tumor Mıcroenvironment on T Cell Responses in a Rat Chemical Mammary Carcinoma Model
(Kanser Enstitüsü, 2013)The studies that have investigated the nature of the cells and molecules responsible for the functional insufficiency of the tumor infiltrating T cells usually on several components; however, the contribution of stromal ... -
The Role of Regnase-1 Protein in Sculpting of Tumor Microenvironment
(Kanser Enstitüsü, 2021)The tumor microenvironment (TME) contains cancer-associated fibroblasts (CAFs) and their tumor-supportive role helps to build an environment in favor of cancer cell progression. Recent researches have revealed that targeting ... -
Tip-1 Yardımcı T (Th1) Hücrelerin Radyasyon Stresi Altında Fonksiyonel ve Fenotipik Değişimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022-07-18)It's critical to understand changes in the functional and phenotypic status of T cells, which play a key role in the anti-tumor response due to the immunosuppressive environment in the tumor microenvironment. In chronic ... -
Tüm Beden Işınlamalarında Farklı Tedavi Planlama Tekniklerinin Dozimetrik Olarak Karşılaştırılması
(Kanser Enstitüsü, 2021-02-10)The purpose of Total Body Irradiation (TBI) in radiotherapy is to suppress the immune system of the patient by destroying bone marrow cells, prepare the host for bone marrow transplantation and enhance the antitumor effect. ... -
Vajinal Kaf Brakiterapi Uygulamaları için Yoğunluk Ayarlı Aplikatör Tasarımı: Dozimetrik Fizibilite Çalışması
(Kanser Enstitüsü, 2018)Depending on technological advances in radiotherapy, the use of three-dimensional (3D) treatment planning in brachytherapy (BRT) applications has provided a great advantage in terms of efficacy of treatment in gynecological ... -
Vulva Kanserinde Elektron-YART Hibrit Tedavi Modalitesinin Tedavi Planlama Sistemi ve Dozimetrik Yöntemlerle İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-02-20)In recent years, in the treatment of vulvar cancer, intensity modulated radiation therapy (IMRT) have been used instead of 3 dimensional conformal radiotherapy (3DCRT). In this thesis study, 7 patients who were diagnosed ... -
Vücut Içerisindeki Doku Eşdeğeri Olmayan Implant Materyallerinin Yoğunluk Ayarlı Radyoterapi ve Stereotaktik Radyocerrahi Tedavilerinde Doz Dağılımına Etkisinin İncelenmesi
(Kanser Enstitüsü, 2015)Several cancer patients, who have implant and filling material in their body, are treated with radiotherapy and those materials may cause dosimetric uncertainities during treatment which may not be estimated accurately by ... -
Yoğunluk Ayarlı Radyoterapi Tekniğinde İn Vivo Dozimetri İçin Elektronik Portal Görüntüleme Sistemi ve Diyot Dedektörlerin Kullanılması
(Kanser Enstitüsü, 2013)Intensity Modulated Radiation Therapy (IMRT) is an advanced method of three-dimensional conformal radiotherapy techniques. Patient-specific quality assurances are very important for IMRT technic. These assurances are often ...