Akut Uzun Süreli Doğa Koşusunun Serum Miyokin Seviyelerine Etkisi

Abstract

In this study, it was aimed to investigate the changes in levels of IL-6 and IL-15 which are peptides called myokines, synthesized from muscle tissue and known to have endocrine affects, after a long-distance trail run. There is no study showing the level of IL-15 after long-distance running, while long lasting concentric exercise involving large muscle groups is known to increase IL-6 levels. However, it is expected that IL-15, which is known to increase due to muscle contraction, also increases after long-distance trail run, in this contezt hypothesis of this research was that following a long distance trail run, levels of both IL-6 and IL-15 would be elevated. For this purpose, blood samples were collected from 37 athletes (11 women, 26 men) who were to run the 30 + km course of the Cappadocia UltraTrail before and after the run and demographic information and training status of the athletes’ were recorded. Serum IL-6 and IL-15 levels were analyzed by ELISA. Significant increase was found in both myokines after running. It was observed that the level of IL-6 increased to about 13.2 times after running and the level of IL-15 to 2.22 times. (p<0.001 and p<0.001, respectively) It was seen that this increase was not affected by the person's body mass index, the number of years of running, the weekly training period and distance. The level of basal IL-15 was lower (p = 0.04) in the under-35 age group (p = 0.04), but this difference did not affect the amount of IL-15 increase after running. The results support our hypothesis that the long-distance trail run leads to a significant increase in IL-6 and IL-15 levels in serum.