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dc.contributor.authorPiñana, JL
dc.contributor.authorXhaard, A
dc.contributor.authorTridello, g
dc.contributor.authorPassweg, j
dc.contributor.authorkozijn, A
dc.contributor.authorPolverelli, N
dc.contributor.authorHeras, I
dc.contributor.authorPerez, A
dc.contributor.authorSanz, J
dc.contributor.authorBerghuis, D
dc.contributor.authorVázquez, L
dc.contributor.authorSuárez-Lledó, M
dc.contributor.authorItäla-Remes, M
dc.contributor.authorOzcelik T
dc.contributor.authorIturrate Basarán, A
dc.contributor.authorKarakukcu, M
dc.contributor.authorAl Zahrani, M
dc.contributor.authorChoi, G
dc.contributor.authorCuesta Casas, MA
dc.contributor.authorBatlle Massana, M
dc.contributor.authorViviana, A
dc.contributor.authorBlijlevens, N
dc.contributor.authorGanser, A
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorLabussière-Wallet, H
dc.contributor.authorShaw, PJ
dc.contributor.authorArzu Yegin, Z
dc.contributor.authorGonzález-Vicent, M
dc.contributor.authorRocha, V
dc.contributor.authorFerster, A
dc.contributor.authorKnelange, N
dc.contributor.authorNavarro, D
dc.contributor.authorMikulska, M
dc.contributor.authorde la Camara, R
dc.contributor.authorStyczynski, J
dc.date.accessioned2021-09-16T07:36:14Z
dc.date.available2021-09-16T07:36:14Z
dc.date.issued2021-05-20
dc.identifier.urihttp://hdl.handle.net/11655/25330
dc.description.abstractBackground: Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods: This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results: We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 × 109/mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01). Conclusions: Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.tr_TR
dc.language.isoentr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectSeasonal human coronavirustr_TR
dc.titleSeasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.tr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.relation.journalJ Infect Distr_TR
dc.contributor.departmentÇocuk Sağlığı ve Hastalıklarıtr_TR
dc.description.indexWoStr_TR
dc.fundingYoktr_TR


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