Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
dc.contributor.author | Piñana, JL | |
dc.contributor.author | Xhaard, A | |
dc.contributor.author | Tridello, g | |
dc.contributor.author | Passweg, j | |
dc.contributor.author | kozijn, A | |
dc.contributor.author | Polverelli, N | |
dc.contributor.author | Heras, I | |
dc.contributor.author | Perez, A | |
dc.contributor.author | Sanz, J | |
dc.contributor.author | Berghuis, D | |
dc.contributor.author | Vázquez, L | |
dc.contributor.author | Suárez-Lledó, M | |
dc.contributor.author | Itäla-Remes, M | |
dc.contributor.author | Ozcelik T | |
dc.contributor.author | Iturrate Basarán, A | |
dc.contributor.author | Karakukcu, M | |
dc.contributor.author | Al Zahrani, M | |
dc.contributor.author | Choi, G | |
dc.contributor.author | Cuesta Casas, MA | |
dc.contributor.author | Batlle Massana, M | |
dc.contributor.author | Viviana, A | |
dc.contributor.author | Blijlevens, N | |
dc.contributor.author | Ganser, A | |
dc.contributor.author | Kuskonmaz, Baris | |
dc.contributor.author | Labussière-Wallet, H | |
dc.contributor.author | Shaw, PJ | |
dc.contributor.author | Arzu Yegin, Z | |
dc.contributor.author | González-Vicent, M | |
dc.contributor.author | Rocha, V | |
dc.contributor.author | Ferster, A | |
dc.contributor.author | Knelange, N | |
dc.contributor.author | Navarro, D | |
dc.contributor.author | Mikulska, M | |
dc.contributor.author | de la Camara, R | |
dc.contributor.author | Styczynski, J | |
dc.date.accessioned | 2021-09-16T07:36:14Z | |
dc.date.available | 2021-09-16T07:36:14Z | |
dc.date.issued | 2021-05-20 | |
dc.identifier.uri | http://hdl.handle.net/11655/25330 | |
dc.description.abstract | Background: Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods: This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results: We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 × 109/mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01). Conclusions: Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity. | tr_TR |
dc.language.iso | en | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.subject | Seasonal human coronavirus | tr_TR |
dc.title | Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. | tr_TR |
dc.type | info:eu-repo/semantics/article | tr_TR |
dc.relation.journal | J Infect Dis | tr_TR |
dc.contributor.department | Çocuk Sağlığı ve Hastalıkları | tr_TR |
dc.description.index | WoS | tr_TR |
dc.funding | Yok | tr_TR |