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dc.contributor.authorAyazgoek, Beyza
dc.contributor.authorKucukkilinc, Tuba Tueylue
dc.date.accessioned2021-06-03T09:00:39Z
dc.date.available2021-06-03T09:00:39Z
dc.date.issued2019
dc.identifier.issn1095-6670
dc.identifier.urihttp://dx.doi.org/10.1002/jbt.22233
dc.identifier.urihttp://hdl.handle.net/11655/24370
dc.description.abstractBisphenol A (BPA) is an endocrine disruptor chemical, which is commonly used in everyday products. Adverse effects of its exposure are reported even at picomolar doses. Effects of picomolar and nanomolar concentrations of BPA on cytotoxicity, nitric oxide (NO) levels, acetylcholinesterase (AChE) gene expression and activity, and tumor necrosis factor-alpha (TNF-alpha) and caspase-8 levels were determined in SH-SY5Y cells. The current study reveals that low-dose BPA treatment induced cytotoxicity, NO, and caspase-8 levels in SH-SY5Y cells. We also evaluated the mechanism underlying BPA-induced cell death. Ours is the first report that receptor-interacting serine/threonine-protein kinase 1-mediated necroptosis is induced by nanomolar BPA treatment in SH-SY5Y cells. This effect is mediated by altered AChE and decreased TNF-alpha levels, which result in an apoptosis-necroptosis switch. Moreover, our study reveals that BPA is an activator of AChE.
dc.language.isoen
dc.relation.isversionof10.1002/jbt.22233
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectacetylcholinesterase
dc.subjectbisphenol A
dc.subjectnecroptosis
dc.subjectTNF-alpha
dc.titleLow-Dose Bisphenol A Induces Ripk1-Mediated Necroptosis In Sh-Sy5Y Cells: Effects On Tnf-Alpha And Acetylcholinesterase
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of Biochemical And Molecular Toxicology
dc.contributor.departmentBiyokimya
dc.identifier.volume33
dc.identifier.issue1
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
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