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dc.contributor.authorGenc, Yasin
dc.contributor.authorDereli, Fatma Tugce Guragac
dc.contributor.authorSaracoglu, Iclal
dc.contributor.authorAkkol, Esra Kupeli
dc.date.accessioned2021-06-03T08:50:27Z
dc.date.available2021-06-03T08:50:27Z
dc.date.issued2020
dc.identifier.issn1319-0164
dc.identifier.urihttp://dx.doi.org/10.1016/j.jsps.2019.11.011
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950955/
dc.identifier.urihttp://hdl.handle.net/11655/24339
dc.description.abstractPlantago major L. which is a medicinal plant with important biological activities, commonly used as traditional medicine. Potential inhibitory activities of the aqueous extract and three isolated constituents calceorioside B (1), homoplantaginin (hispidulin-7-O-glucoside) (2) and plantamajoside (3) from the aerial parts of Plantago major subsp. major L. (Plantaginaceae) have been tested against hyaluronidase, collagenase, and elastase, which play critical roles in wound pathogenesis. Even though, the extract (27.04%), and among the isolated compounds, calceorioside B (41.16%) exerted significant inhibition against hyaluronidase enzyme, homoplantaginin and plantamajoside were found to be inactive. Similar results were obtained from collagenase enzyme inhibition test. The extract (21.92%) and calceorioside B (28.34%) also caused notable inhibition in this test. However, no remarkable inhibition was observed in the presence of elastase enzyme. The experimental data revealed that P. major subsp. major displayed remarkable inhibitory activity against hyaluronidase and collagenase enzymes. In vitro enzyme activity of P. major subsp. major is reported for the first time in the current study.
dc.language.isoen
dc.relation.isversionof10.1016/j.jsps.2019.11.011
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Inhibitory Effects Of Isolated Constituents From Plantago Major Subsp. Major L. On Collagenase, Elastase And Hyaluronidase Enzymes: Potential Wound Healer
dc.title.alternativeThe inhibitory effects of isolated constituents from Plantago major subsp. major L. on collagenase, elastase and hyaluronidase enzymes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalSaudi Pharmaceutical Journal : Spj
dc.contributor.departmentFarmakognozi
dc.identifier.volume28
dc.identifier.issue1
dc.description.indexPubMed


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Attribution 4.0 United States
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