dc.contributor.author | Basaran, Hamit | |
dc.contributor.author | Cengiz, Mustafa | |
dc.contributor.author | Yazici, Gozde | |
dc.contributor.author | Susulu, Nilda | |
dc.contributor.author | Aksoy, Sercan | |
dc.contributor.author | Hosal, Ali Sefik | |
dc.contributor.author | Gullu, Ibrahim H. | |
dc.contributor.author | Ozyigit, Gokhan | |
dc.date.accessioned | 2021-06-03T05:42:58Z | |
dc.date.available | 2021-06-03T05:42:58Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1306-133X | |
dc.identifier.uri | http://dx.doi.org/10.4999/uhod.193853 | |
dc.identifier.uri | http://hdl.handle.net/11655/24117 | |
dc.description.abstract | This study aimed to evaluate survival in patients with locally advanced nasopharyngeal carcinoma. The records of 407 patients with locally advanced nasopharyngeal carcinoma treated retrospectively reviewed. Patients were treated with 5 different treatment protocols: 22.4% patients received radiotherapy, 16.4% received concomitant chemoradiotherapy, 11.3% received concomitant chemoradiotherapy + adjuvant chemotherapy, 30.7% received neoadjuvant chemotherapy + concomitant chemoradiotherapy, and 19.2% received neoadjuvant chemotherapy + radiotherapy. At the median follow-up of 64 months 5-year and 10-year overall survival were 64.6% and 55.3%, respectively, and 5-year and 10-year locoregional relapse-free survival were 58.5% and 49.2%, respectively. Age <40 years (p< 0.001) and early stage (p= 0.014) were associated with better survival. Among the treatment protocols, neoadjuvant chemotherapy + radiotherapy yielded the best survival (p= 0.001). Concomitant chemoradiotherapy was not associated with any survival advantage; however, the addition of chemotherapy to concomitant chemoradiotherapy prolonged survival, regardless of radiotherapy schedule. The present findings show that the addition of chemotherapy, especially neoadjuvantly, improved overall survival. | |
dc.language.iso | en | |
dc.relation.isversionof | 10.4999/uhod.193853 | |
dc.rights | Attribution 4.0 United States | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Concomitant Chemoradiotherapy | |
dc.subject | Nasopharyngeal Carcinoma | |
dc.subject | Neoadjuvant chemotherapy | |
dc.subject | Survival | |
dc.title | Neoadjuvant Chemotherapy Improves Survival In Patients With Locally Advanced Nasopharyngeal Carcinoma | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Uhod-Uluslararasi Hematoloji-Onkoloji Dergisi | |
dc.contributor.department | Radyasyon Onkolojisi | |
dc.identifier.volume | 29 | |
dc.identifier.issue | 3 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |