dc.contributor.author | Babaoglu, Hakan | |
dc.contributor.author | Baytaroglu, Ata | |
dc.contributor.author | Torgutalp, Murat | |
dc.contributor.author | Erden, Abdulsamet | |
dc.contributor.author | Kadayifcilar, Sibel | |
dc.contributor.author | Kalyoncu, Umut | |
dc.date.accessioned | 2021-06-03T05:20:04Z | |
dc.date.available | 2021-06-03T05:20:04Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.uri | http://dx.doi.org/10.3906/sag-1806-1 | |
dc.identifier.uri | http://hdl.handle.net/11655/23974 | |
dc.description.abstract | Background/aim: We aimed to assess the association between retinal vascular caliber (RVC) scores and disease activity in rheumatoid arthritis (RA) patients. Materials and methods: Forty-seven RA patients, 32 systemic lupus erythematosus (SLE) patients, and 45 healthy people were enrolled. RA and SLE patients were subdivided into groups according to C- reactive protein (CRP) levels. RA patients were also grouped according to Disease Activity Score-28 (DAS-28). Fundus photography was performed for all patients. RVC was summarized as the central retinal artery and vein equivalents (CRAE and CRVE). Results: Mean CRVE for RA patients was 213.3 +/- 17.8 mu m compared with 209.2 +/- 14.1 mu m for SLE and 217.5 +/- 26.2 mu m for the control group (P = 0.17). RVC scores did not differ between the CRP-high and CRP-low groups. As the RA disease activity increased, the widening of CRVE became more prominent and statistically significant. When the DAS-28 > 5.1 (CRVE, 220.4 (211.8-246.5) mu m) group and DAS-28 15 <= 3.2 (CRVE, 214.4 (172.4-242.3) mu m) group were compared, statistical significance was more pronounced (P = 0.03) than when comparing the DAS-28 > 3.2 and DAS-28 <= 3.2 groups (P= 0.05). Conclusion: CRVE, which reflects systemic inflammation and possibly increased cardiovascular risk, was significantly increased in active RA patients. The association between retinal venular widening and disease activity, regardless of CRP, may be a sign that RA-related inflammation may have systemic vascular effects even with normal levels of CRP. | |
dc.language.iso | en | |
dc.relation.isversionof | 10.3906/sag-1806-1 | |
dc.rights | Attribution 4.0 United States | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | cardiovascular risk | |
dc.subject | microvascular health | |
dc.subject | retinal vascular caliber | |
dc.subject | Rheumatoid arthritis | |
dc.title | Abnormal Retinal Microvasculature Found In Active Rheumatoid Arthritis: A Different Perspective Of Microvascular Health | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Medical Sciences | |
dc.contributor.department | İç Hastalıkları | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 1 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |