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dc.contributor.authorYalcin, Sıdıka Songul
dc.contributor.authorKondolot, Meda
dc.contributor.authorGoker, Hakan
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorKaracan, Y
dc.contributor.authorCetin, Mualla
dc.contributor.authorAksu, Salih
dc.contributor.authorTezcan, Ilhan
dc.contributor.authorUckan, Duygu
dc.date.accessioned2020-10-21T12:39:53Z
dc.date.available2020-10-21T12:39:53Z
dc.date.issued2011
dc.identifier.issn1469-4409
dc.identifier.urihttp://hdl.handle.net/11655/23009
dc.identifier.urihttps://doi.org/10.1017/S0950268810001585
dc.description.abstractHaematopoietic stem cell transplant (HSCT) recipients lose immune memory of exposure to infectious agents and vaccines accumulated throughout their lifetime and therefore need to be revaccinated. We aimed to evaluate the influence of different factors on hepatitis A virus (HAV) immunity in both child and adult HSCT recipients living in an intermediate endemic region, Turkey. Eighty patients (age range 2. 5–57 years) who had HAV serology prior to HSCT were evaluated. The prevalence of HAV seropositivity was 85% (n=68) before HSCT. There was no history of HAV vaccination before HSCT in children and HAV vaccine was not available in Turkey 10 years ago, so it was assumed that all seropositive patients reflected natural immunity. After the exclusion of six patients with autologous HSCT, the remaining 62 seropositive and allogeneic patients were included in this retrospective study. The duration of HAV seropositivity was estimated using the Kaplan–Meier method, log-rank analysis and Cox regression models. Estimated mean time to loss of HAV seropositivity was 48. 6 months after transplantation. Patients who were older (o18 years) at transplantation and who had older (o18 years) donors became seronegative later (P<0. 05). Cox backward-stepwise regression confirmed that older age of recipient at transplantation was the only significant parameter for HAV seropositivity (P<0. 05). HAV-inactivated vaccine might be recommended later to older HSCT recipients in intermediate endemic regions
dc.language.isoentr_TR
dc.publisherCambridge University Press
dc.relation.isversionof10.1017/S0950268810001585
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHepatitis A antibodiestr_TR
dc.subjectHaematopoetic stem cell transplantation
dc.titleNaturally Acquired Hepatitis a Antibodies After Haematopoetic Stem Cell Transplantationtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalEpidemiology and Infection
dc.contributor.departmentÇocuk Sağlığı ve Hastalıklarıtr_TR
dc.identifier.volume139
dc.identifier.startpage683
dc.identifier.endpage687
dc.description.indexWoStr_TR
dc.fundingYoktr_TR


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