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dc.contributor.authorInkaya, Ahmet Cagkan
dc.contributor.authorAktug, Nazlim
dc.contributor.authorKolgelier, Servet
dc.contributor.authorSumer, Sua
dc.contributor.authorDemir, Lutfi Saltuk
dc.contributor.authorUral, Onur
dc.contributor.authorPehlivan, Fatma Seher
dc.contributor.authorAslan, Mahmure
dc.contributor.authorArpaci, Abdullah
dc.date.accessioned2020-01-17T11:21:14Z
dc.date.available2020-01-17T11:21:14Z
dc.date.issued2017
dc.identifier.issn0025-7974
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000007547
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392731/
dc.identifier.urihttp://hdl.handle.net/11655/21798
dc.description.abstractBackground: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis. Method: This cross-sectional case-control study included 189 chronic hepatitis B (CHB) patients and 51 healthy controls. All patients underwent liver biopsy and modified Knodell scoring system used to determine the fibrosis level in CHB patients. Serum HMGB1 levels were determined with enzyme-linked immunosorbent assay (ELISA). Results: Mean serum HMGB1 levels of patients (58.1 ± 54.7) were found to be higher than those of the control group (7.1 ± 4.3) (P = .001). HMGB1 levels of patients with advanced-stage fibrosis (stage 4 and 5) were detected to be higher than those of patients with early-stage fibrosis (stage 1–3). However, this difference was not statistically significant (P > .05). Albumin levels of fibrosis 3 and 4 patients were lower than fibrosis 1 and 2 patients. ALT, HBV DNA, and AFP levels of fibrosis 5 patients were significantly higher than fibrosis 1 and 2 patients, and their platelet and albumin levels are lower than fibrosis 1 and 2 patients (P < .001). In a logistic regression model, fibrosis levels were correlated with ALT values and inversely correlated with albumin levels. Conclusion: In this study, we demonstrated that serum HMGB1 levels increase in the early course of liver injury and this increase is not correlated with severity of the liver damage.tr_TR
dc.language.isoentr_TR
dc.publisherWolters Kluwertr_TR
dc.relation.isversionof10.1097/MD.0000000000007547tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectAlarmin moleculestr_TR
dc.subjectChronic hepatitis Btr_TR
dc.subjectHigh-mobility group box 1tr_TR
dc.subjectLiver fibrosistr_TR
dc.subject.lcshKonu Başlıkları Listesi::Tıptr_TR
dc.titleIs Serum High-Mobility Group Box 1 (Hmgb-1) Level Correlated with Liver Fibrosis in Chronic Hepatitis B?tr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalMedicinetr_TR
dc.contributor.departmentMikrobiyolojitr_TR
dc.identifier.volume96tr_TR
dc.identifier.issue36tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.endpage4tr_TR
dc.description.indexWoStr_TR
dc.description.indexScopustr_TR
dc.description.indexPubMedtr_TR
dc.fundingYoktr_TR


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