Protein C Saflaştırılması İçin Moleküler Baskılanmış Adsorbentler

Abstract

Protein C (PC) is the pivotal anticoagulant and antithrombotic in the human coagulation cascade. Protein C is showed its anticoagulant effect with Protein S (PS) by inactivating FVa and FVIIIa. PC is at a concentration of 4 μg mL in human blood. In the absence of Protein C (Protein C deficiency) increases risk of generation thrombosis. When these blood clots break away from the surface of the vein and enter the blood stream, they will induce strokes, heart attacks and pulmonary embolisms. Blood clotting can be life threatening if it is not recognized early and treated. Heparin and coumadin are commonly used to the treatment for protein C deficient patients. However, these therapeutics have dangerous side effects as excessive bleeding, stroke, organ failure.