Show simple item record

dc.contributor.authorHarput, Ummuhan Sebnem
dc.contributor.authorNagatsu, Akito
dc.contributor.authorSaracoglu, Iclal
dc.date.accessioned2019-12-16T10:29:39Z
dc.date.available2019-12-16T10:29:39Z
dc.date.issued2012
dc.identifier.issn1307-6167
dc.identifier.urihttps://doi.org/
dc.identifier.urihttp://hdl.handle.net/11655/20152
dc.description.abstractThe water extract of M. aurea exhibited strong scavenging effect on 2,2-diphenyl-1-picrylhydrazil (DPPH), nitric oxide (NO) and superoxide (SO) radicals. The free radical scavenging effect of the extract was found comparable to that of reference antioxidants, 3-t-butyl-4-hydroxyanizole (BHA) and ascorbic acid (AA, vitamin C). Cytotoxic activity of the extract was also investigated against three different cancer cell lines, Hep-2 (human larynx epidermoid carcinoma), RD (human rhabdomyosarcoma), L-20B (transgenic murine L-cells) and one non-cancerous cell line (VERO-African green monkey kidney epithelial cell) using 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenytetrazolium bromide (MTT) assay. While dose dependent cytotoxic activity was observed against cancer cell lines, no cytotoxic effect on VERO cell line was found in the tested experiments. In addition, phytochemical investigations to identify chemical content of the plant were resulted to the isolation of (+)-syringaresinol-4'-O-b-glucopyranoside (1), p-hydroxybenzaldehyde (2), quercetin-3-O-rutinoside (Rutine, 3) and isorhamnetin-3-O-rutinoside (4) on the basis of different spectroscopic techniques (UV, IR, 1D and 2D NMR, HR ESI-MS).
dc.language.isoen
dc.publisherAcg Publications
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlant Sciences
dc.subjectChemistry
dc.subjectPharmacology & Pharmacy
dc.titleAntioxidant and Cytotoxic Effects of Moltkia Aurea Boiss
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalRecords Of Natural Products
dc.contributor.departmentEczacılık Temel Bilimleri
dc.identifier.volume6
dc.identifier.issue1
dc.identifier.startpage62
dc.identifier.endpage66
dc.description.indexWoS


Files in this item

This item appears in the following Collection(s)

Show simple item record