dc.contributor.author | Yilmaz, Necat | |
dc.contributor.author | Herken, Hasan | |
dc.contributor.author | Cicek, Huelya Kanbur | |
dc.contributor.author | Celik, Ahmet | |
dc.contributor.author | Yuerekli, Muhittin | |
dc.contributor.author | Akyol, Oemer | |
dc.date.accessioned | 2019-12-16T10:29:23Z | |
dc.date.available | 2019-12-16T10:29:23Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1011-7571 | |
dc.identifier.uri | https://doi.org/10.1159/000098367 | |
dc.identifier.uri | http://hdl.handle.net/11655/20111 | |
dc.description.abstract | Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic schizophrenia and 28 normal male subjects participated in this study. The duration of disease was 145 +/- 120 (mean +/- SD) months. Serum levels of cortisol and DHEA-S were measured by electrochemiluminescence; plasma nitrite levels as an index of NO were measured with the Griess reaction, while plasma AM concentration was measured by using high-performance liquid chromatography. Results: Patients (12.48 +/- 3.2 mu g/dl), as compared to controls (10.31 +/- 3.1 mu g/dl), had higher levels of baseline cortisol (p < 0.05). DHEA-S levels were lower in patients though this did not reach statistical significance (302 +/- 156 mu g/dl compared to control, 322 +/- 96 mu g/dl, p 1 0.05). The mean levels of plasma AM and NO in the schizophrenic group (44.33 +/- 5.07 pmol/l and 36.27 +/- 17.6 mu mol/l) were significantly higher than the levels in the control group (14.56 +/- 4.03 pmol/l and 32.54 +/- 7.14 mu mol/l; p < 0.001, p < 0.03, respectively). There was a positive association between duration of disease and cortisol/DHEA-S ratio and cortisol level. Conclusion: The data show that schizophrenia is associated with abnormal levels of cortisol, DHEA-S, NO and AM. Copyright (C) 2007 S. Karger AG, Basel. | |
dc.language.iso | en | |
dc.publisher | Karger | |
dc.relation.isversionof | 10.1159/000098367 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | General & Internal Medicine | |
dc.title | Increased Levels Of Nitric Oxide, Cortisol And Adrenomedullin In Patients With Chronic Schizophrenia | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Medical Principles And Practice | |
dc.contributor.department | Biyokimya | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 137 | |
dc.identifier.endpage | 141 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |