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dc.contributor.authorAkgeyik, Emrah
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorCelebier, Mustafa
dc.contributor.authorAltinoz, Sacide
dc.contributor.authorSahin, Selma
dc.date.accessioned2019-12-16T10:29:21Z
dc.date.available2019-12-16T10:29:21Z
dc.date.issued2016
dc.identifier.issn1521-298X
dc.identifier.urihttps://doi.org/10.14227/DT230216P36
dc.identifier.urihttp://hdl.handle.net/11655/20098
dc.description.abstractThe aim of this study was to evaluate the quality of conventional paracetamol- (PA) and caffeine- (CA) containing combined dosage forms in the Turkish drug market. For this purpose, weight variation, content uniformity, diameter and thickness, hardness, friability, disintegration, and dissolution tests were carried out. Content uniformity and dissolution tests were performed by a validated high-performance liquid chromatography (HPLC) method. Separations were carried on an ACE 5-C-18, 5-mu m LC column (250 x 4.6 mm) using isocratic elution with a methanol/water (40:60 v/v) mobile phase. The injection volume was 20 mu L, and UV detection was performed at 270 nm. The weight variation results were in accordance with content uniformity results. All dosage forms fulfilled the USP requirement of not less than 75% of active ingredients of the labeled claim dissolved within 60 min. Also, all tablets met the rapidly dissolving criterion (more than 85% of the labeled amount of the drug substance dissolved within 30 min). The results of this study indicate that PA- and CA-containing conventional dosage forms available in the Turkish drug market pass all the established quality control tests successfully, and they can be used interchangeably.
dc.language.isoen
dc.publisherDissolution Technologies, Inc
dc.relation.isversionof10.14227/DT230216P36
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPharmacology & Pharmacy
dc.titleEvaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In The Turkish Drug Market
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalDissolution Technologies
dc.contributor.departmentAnalitik Kimya
dc.identifier.volume23
dc.identifier.issue2
dc.identifier.startpage36
dc.identifier.endpage41
dc.description.indexWoS
dc.description.indexScopus


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