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dc.contributor.authorUgurlu, Nagihan
dc.contributor.authorYulek, Fatma
dc.contributor.authorErgun, Sule Berk
dc.contributor.authorAsik, Mehmet Dogan
dc.contributor.authorIsikoglu, Semra
dc.contributor.authorAkcay, Emine
dc.date.accessioned2019-12-16T09:57:12Z
dc.date.available2019-12-16T09:57:12Z
dc.date.issued2013
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1206-22
dc.identifier.urihttp://hdl.handle.net/11655/19850
dc.description.abstractAim: To investigate the oxidative and antioxidative status in diabetic patients with cataracts and nondiabetic patients with cataracts as compared to controls. Materials and methods: There were 149 subjects included in the present study. Blood was collected from type 2 diabetic patients suffering from cataracts (diabetic cataract; n = 42), senile nondiabetic patients suffering from cataracts (nondiabetic cataracts; n = 60), and healthy subjects of a control group (n = 47). Serum levels of total oxidant status (TOS), total antioxidant status (TAS), total thiol levels (TTLs), and paraoxonase 1 (PON1) were investigated in the samples. Results: TTLs were significantly reduced in diabetic cataract patients (444.8 mu mol/L) compared with both nondiabetic cataract patients (525.1 mu mol/L) and the control group (569.9 mu mol/L). Plasma PON1 levels also were significantly reduced in diabetic cataract patients (241.9 U/L) relative to the control group (178.3 U/L). There were no statistically significant differences between TAS and TOS levels among groups. Conclusion: The present study demonstrates a significant reduction in serum TTLs and serum PON1 activities in diabetic cataract patients compared with controls. These findings represent a failure in the antioxidant system, which may be related to the cataractogenic process.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1206-22
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleInvestigation of Oxidative and Antioxidative Status in Patients with Diabetic Cataracts
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentNanoteknoloji ve Nanotıp
dc.identifier.volume43
dc.identifier.issue5
dc.identifier.startpage678
dc.identifier.endpage683
dc.description.indexWoS
dc.description.indexScopus


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