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dc.contributor.authorAlbayrak, Murat
dc.contributor.authorCelebi, Harika
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorSayilir, Abdurrahim
dc.contributor.authorYesil, Yusuf
dc.contributor.authorBalcik, Ozlem Sahin
dc.contributor.authorYokus, Osman
dc.contributor.authorCelik, Tugrul
dc.date.accessioned2019-12-16T09:18:51Z
dc.date.available2019-12-16T09:18:51Z
dc.date.issued2012
dc.identifier.issn1470-3203
dc.identifier.urihttps://doi.org/10.1177/1470320312437070
dc.identifier.urihttp://hdl.handle.net/11655/19623
dc.description.abstractIntroduction: Angiotensin converting enzyme (ACE) is a circulating enzyme that participates in the body's renin-angiotensin system (RAS) and is localized on the endothelial cell surface in the lung and other vascular beds. It catalyses the conversion of decapeptide angiotensin I to octapeptide angiotensin II. In the present study, we aimed to analyse the possible relationship between the levels of ACE in the context of RAS in multiple myeloma (MM) pathogenesis. Materials and methods: The study was conducted on 25 MM patients (13 males, 12 females; median age 66 years, range 47-88) and 20 healthy controls. The clinical features of MM patients including demographics and laboratory findings were summarized. Serum ACE levels were measured by using commercially available kits. Results: The serum ACE levels of MM patients and controls were 32.60 +/- 20.26 and 15.35 +/- 6.47 respectively. Serum ACE levels were significantly higher in MM patients compared with control groups (p<0.001). Conclusions: Being an important component of RAS, circulating ACE might be associated with clonal proliferation of malignant plasma cells in the bone marrow microenvironment. Identification of the pathobiological activity of the local RAS in MM would enlighten the biologic basis and clinical management of haematologic disorders.
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.isversionof10.1177/1470320312437070
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular System & Cardiology
dc.titleElevated Serum Angiotensin Converting Enzyme Levels As A Reflection Of Bone Marrow Renin-Angiotensin System Activation In Multiple Myeloma
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of The Renin-Angiotensin-Aldosterone System
dc.contributor.departmentKimya
dc.identifier.volume13
dc.identifier.issue2
dc.identifier.startpage259
dc.identifier.endpage264
dc.description.indexWoS
dc.description.indexScopus


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