dc.contributor.author | Akca, Kivanc | |
dc.contributor.author | Sarac, Ebru | |
dc.contributor.author | Baysal, Ugur | |
dc.contributor.author | Fanuscu, Mete | |
dc.contributor.author | Chang, Ting-Ling | |
dc.contributor.author | Cehreli, Murat | |
dc.date.accessioned | 2019-12-16T07:02:28Z | |
dc.date.available | 2019-12-16T07:02:28Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1746-160X | |
dc.identifier.uri | https://doi.org/10.1186/1746-160X-3-28 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1947957/ | |
dc.identifier.uri | http://hdl.handle.net/11655/19173 | |
dc.description.abstract | Background Osteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats. Methods Fifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed en bloc and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 μm wide peri-implant volume of interest (VOI). Results Mean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (P < .05). Differences in trabecular-thickness and -separation around implants in all groups were similar (P > .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (P < .05). Conclusion Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume. | |
dc.relation.isversionof | 10.1186/1746-160X-3-28 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Micro-Morphologic Changes Around Biophysically-Stimulated Titanium Implants In Ovariectomized Rats | |
dc.type | info:eu-repo/semantics/article | |
dc.relation.journal | Head & Face Medicine | |
dc.contributor.department | Protetik Diş Tedavisi | |
dc.identifier.volume | 3 | |
dc.identifier.startpage | 28 | |
dc.description.index | PubMed | |
dc.description.index | Scopus | |