dc.contributor.author | Ozer, Taha | |
dc.contributor.author | Akta, Alper | |
dc.contributor.author | Bari, Emre | |
dc.contributor.author | Celik, Hakan Hamdi | |
dc.contributor.author | Vatansever, Alper | |
dc.date.accessioned | 2019-12-16T06:18:25Z | |
dc.date.available | 2019-12-16T06:18:25Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0102-8650 | |
dc.identifier.uri | https://doi.org/10.1590/s0102-865020170090000010 | |
dc.identifier.uri | http://hdl.handle.net/11655/19017 | |
dc.description.abstract | Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification. | |
dc.language.iso | en | |
dc.publisher | Acta Cirurgica Brasileira | |
dc.relation.isversionof | 10.1590/s0102-865020170090000010 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Surgery | |
dc.title | Effects Of Local Alendronate Administration On Bone Defect Healing. Histomorphometric And Radiological Evaluation In A Rabbit Model | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Acta Cirurgica Brasileira | |
dc.contributor.department | Ağız Diş ve Çene Cerrahisi | |
dc.identifier.volume | 32 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 781 | |
dc.identifier.endpage | 795 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |