dc.contributor.author | Sahin Yaglioglu, Ayse | |
dc.contributor.author | Senoz, Hulya | |
dc.date.accessioned | 2019-12-13T11:04:58Z | |
dc.date.available | 2019-12-13T11:04:58Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1300-0527 | |
dc.identifier.uri | https://doi.org/10.3906/kim-1612-42 | |
dc.identifier.uri | http://hdl.handle.net/11655/18982 | |
dc.description.abstract | Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a-g) were synthesized and characterized by elemental analysis, H-1 NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a-g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (-H, -CH3, and A) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated. The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than -CH3 and -H substituents. 3a-g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a-g may be anticancer drug candidates. | |
dc.language.iso | en | |
dc.publisher | Scientific Technical Research Council Turkey-Tubitak | |
dc.relation.isversionof | 10.3906/kim-1612-42 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Chemistry | |
dc.subject | Engineering | |
dc.title | Synthesis of Novel 5-Substituted Phenyl-3-(P-Isopropylpheny1)-1-Phenylformazan and Their Biological Activities | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Chemistry | |
dc.contributor.department | Kimya Mühendisliği | |
dc.identifier.volume | 41 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 883 | |
dc.identifier.endpage | 891 | |
dc.description.index | WoS | |