dc.contributor.author | Tok, Tugba Taskin | |
dc.contributor.author | Ozasik, Ozgun | |
dc.contributor.author | Sarigol, Deniz | |
dc.contributor.author | Baran, Ayse Uzgoren | |
dc.date.accessioned | 2019-12-13T11:04:54Z | |
dc.date.available | 2019-12-13T11:04:54Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1300-0527 | |
dc.identifier.uri | https://doi.org/10.3906/kim-1401-91 | |
dc.identifier.uri | http://hdl.handle.net/11655/18976 | |
dc.description.abstract | A series of N-acylhydrazone derivatives (2a-2p) containing 6-methoxy-naphthalene and acylhydrazone moieties were synthesized in good yield using microwave irradiation and developed as potential COX-2 inhibitors. Furthermore, the interactions between COX-2 and the compounds were examined in detail by molecular modeling studies such as structure activity relationship and molecular docking performed using Gaussian 09 and Discovery Studio 3.5. As a result, it was found that N-acylhydrazone compounds displayed a different mechanism than SC-558 as COX-2 inhibitor by binding to different active sites of the protein, COX-2. Compound 2c would be a good COX-2 inhibitor candidate for preclinical studies. | |
dc.language.iso | en | |
dc.publisher | Scientific Technical Research Council Turkey-Tubitak | |
dc.relation.isversionof | 10.3906/kim-1401-91 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Chemistry | |
dc.subject | Engineering | |
dc.title | Synthesis and Molecular Modeling Studies of Naproxen-Based Acyl Hydrazone Derivatives | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Chemistry | |
dc.contributor.department | Kimya Mühendisliği | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 64 | |
dc.identifier.endpage | 83 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |