Use Of Spongostan (Tm) For Prevention Of Cranial Subdural Adhesions Following Craniotomy In An Experimental Rabbit Model

Abstract

AIM: Spongostan (TM) is a sterile, water-insoluble, porcine gelatin absorbable sponge, which is widely used as a hemostatic material. The aim of this study is to test the anti-fibrotic capacity of Spongostan (TM), using a craniotomy model in an experimental rabbit model. MATERIAL and METHODS: Eighteen rabbits were divided into two groups: Each group consisted of 9 rabbits, duratomy plus Spongostan (TM) (group 1), and duratomy without Spongostan (TM) (group 2). Right parietal bone was removed via trephine and low speed drill and dura was opened. On the group 1 rabbits, an appropriate piece of Spongostan (TM) was meticulously placed under dural layer. On group 2 rabbits, same procedures were repeated without Spongostan (TM). Histological sections were taken from each group and evaluated for degree of fibrosis and collagen fibers. RESULTS: There was marked increase in number of fibroblasts and collagen fibers in group 2 rabbits, however most of the rabbits in Spongostan (TM) group demonstrate scarce histopathological findings for fibrosis. CONCLUSION: We conclude that an appropriately placed subdural Spongostan (TM) over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical operations.