dc.contributor.author | Erkin, A. | |
dc.contributor.author | Kosemehmetoglu, K. | |
dc.contributor.author | Diler, M. S. | |
dc.contributor.author | Koksal, C. | |
dc.date.accessioned | 2019-12-12T06:41:05Z | |
dc.date.available | 2019-12-12T06:41:05Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1078-5884 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejvs.2012.09.021 | |
dc.identifier.uri | http://hdl.handle.net/11655/16640 | |
dc.description.abstract | Background: Foam sclerosants are widely used in sclerotherapy and have been accepted as more effective than the liquid form; however, there is no consensus about the most applicable and effective concentration. Objective: The aim of this study was to investigate the histopathological changes caused by various widely used concentrations of foam sclerosant Methods: Fifty-six varicose vein segments of 5-10 mm diameter were gently resected and exposed to various concentrations of foam sclerosant (0.5%, 1%, 2%, 3%) for 5 min, and were then prepared for routine histopathological examination. A total damage scoring system, including the presence of endothelial swelling, intimal thickening, cellular vacuolization in the muscle layer, edema in the tunica media and extent of necrosis, was established. Results: The total damage score of the foam sclerosant groups was significantly higher than that of the control group (median 2.75 vs 1, p = 0.007). The highest damage score was achieved by 1% and 2% foam sclerosants (3.5 and 2.5). No significant difference was found among the different concentrations of sclerosant, although the 1% group caused more severe damage at a near significant level (p = 0.074). Conclusion: Significant pathological damage can be caused by even the lowest doses of foam sclerosant The most injurious concentrations were found to be 1% and 2%, morphologically. A working concentration of 1% could thus be preferable to 0.5%, especially in larger veins. Further in-vivo studies are needed in order to validate these findings. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. | |
dc.language.iso | en | |
dc.publisher | W B Saunders Co Ltd | |
dc.relation.isversionof | 10.1016/j.ejvs.2012.09.021 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Surgery | |
dc.subject | Cardiovascular System & Cardiology | |
dc.title | Evaluation Of The Minimum Effective Concentration Of Foam Sclerosant In An Ex-Vivo Study | tr_en |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | European Journal Of Vascular And Endovascular Surgery | |
dc.contributor.department | Tıbbi Patoloji | |
dc.identifier.volume | 44 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 593 | |
dc.identifier.endpage | 597 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |