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dc.contributor.authorAtalay, Ozbeyen
dc.contributor.authorSevim, Handan
dc.contributor.authorKarahisar Turan, Secil
dc.contributor.authorOnur, Mehmet A.
dc.contributor.authorGurpinar, Ozer A.
dc.date.accessioned2019-12-12T06:26:16Z
dc.date.available2019-12-12T06:26:16Z
dc.date.issued2017
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1701-183
dc.identifier.urihttp://hdl.handle.net/11655/16367
dc.description.abstractBackground/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model. Materials and methods: Arteries were pretreated with elastase to create aneurysms. Gelatin matrices containing MSCs were applied to the outer surface of the elastase-treated carotid artery sections. Results: Healing of the aneuritic arteries for which MSC applications were performed was significantly better than in the aneuritic group. The histological structure of the vessels was largely reconstituted, and the contractile force of the MSC-treated group was similar to the untreated healthy group. Conclusions: Application of MSCs facilitates the healing of aneurysms. Hereby, MSC application could be a promising approach for clinical applications after further validation processes are concluded.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1701-183
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleThe Effects of Mesenchymal Stem Cells on the Structure And Contractile Force of the Carotid Artery in a Rat Aneurysm Model
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentFizyoloji
dc.identifier.volume47
dc.identifier.issue5
dc.identifier.startpage1634
dc.identifier.endpage1641
dc.description.indexWoS
dc.description.indexScopus


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