Metilentetrahidrofolat Redüktaz Gen Olimorfizmi Olan Gebe Kadınlarda Antenatal Depresyon ve Bazı Aminoasitlerle İlişkisi

Abstract

Methylenetetrahydrofolate Reductase (MTHFR) is the enzyme converting 5,10-methylenetetrahydrofolate (product of cytosolic serine hydroxymethyltransferase) to 5- methyltetrahydrofolate for homocysteine remethylation. MTHFR gene polymorphism is one of the congenital disorders related with homocysteine metabolism. Both hyperhomocysteinemia’s possible negative effect on woman and fetal health, and homocysteine’s role in depression etiology makes woman prone to antenatal depression. This research is planned for determining amount of nutrients, mainly aminoacids, consumed by pregnant and non-pregnent women with or without MTHFR gene polymorphism, for determining plasma vitamin B12, folate, iron, thyroid stimulating hormone concentrations in maternal venous (14th, 24th, 32nd gestational weeks, at birth) and umblical cord blood and determining apgar scores and the relationship between these parametres and effect of these parametres on antenatal depression. Therefore, we determined that half of the subjects at all subpolymorphism groups had Beck Depression Inventory (BDI) scores convenient for taking depression diagnosis, and one third of the subjects at all sub-polymorphism groups had mild or midgrade anxiety. MTHFR gene polymorhism was statistically related to live birth number (p=0.000, <0.05), number of abortus at 10th and 22nd gestation weeks (p=0.008, < 0.05), birth weight (p=0.003, p<0.05), total pregnancy number (p=0.003, <0.05), and first pregnancy history (p=0.000, <0.05). Umblical cord blood folic acid and vitamin B12 values were statistically related to 14th gestation week iron consumption (p=0,013, <0,05) and 24th gestation week folic acid consumption (p=0,008, <0,05). Postnatal first and fifth minute apgar score was statistically related to and 32nd gestation weeks (p<0,05). Socia support taking situation of pregnant women with MTHFR gene polymorphism was statistically related to BDI scores (p=0.006, <0.05). In conclusion, maternal nutrition can effect newborn’s Apgar score and blood parametres.