Basit öğe kaydını göster

dc.contributor.authorCamm, A. John
dc.contributor.authorAccetta, Gabriele
dc.contributor.authorAl Mahmeed, Wael
dc.contributor.authorAmbrosio, Giuseppe
dc.contributor.authorGoldhaber, Samuel Z.
dc.contributor.authorHaas, Sylvia
dc.contributor.authorJansky, Petr
dc.contributor.authorKayani, Gloria
dc.contributor.authorMisselwitz, Frank
dc.contributor.authorOh, Seil
dc.contributor.authorOto, Ali
dc.contributor.authorRaatikainen, Pekka
dc.contributor.authorSteffel, Jan
dc.contributor.authorvan Eickels, Martin
dc.contributor.authorKakkar, Ajay K.
dc.contributor.authorLucas
dc.date.accessioned2019-12-10T11:23:11Z
dc.date.available2019-12-10T11:23:11Z
dc.date.issued2017
dc.identifier.issn2044-6055
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2016-014579
dc.identifier.urihttp://hdl.handle.net/11655/15542
dc.description.abstractObjectives: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) explored the impact of gender, risk factors and anticoagulant (AC) treatment on 1-year outcomes in patients with nonvalvular atrial fibrillation (NVAF). Design: GARFIELD-AF is a prospective noninterventional registry. Setting: Investigator sites (n= 1048) are representative of the care settings/ locations in each of the 35 countries. Participants: Patients >= 18yrs with newly diagnosed (<= 6 weeks' duration) NVAF and >= 1 investigatordetermined stroke risk factors. Main outcome measures: Event rates per 100 person-years were estimated from the Poisson model and HRs and 95% CIs calculated. Results: Of 28 624 patients (women 44.4%; men 55.6%) enrolled, there were more elderly (>= 75 years) women (46.9%) than men(30.4%).All-cause mortality rates per 100 person-years (95% CI) for women and men were 4.48 (4.12 to 4.87) and 4.04 (3.74 to 4.38), respectively, stroke/ systemic embolism (SE) (1.62 (1.41 to 1.87) and 1.17 (1.01 to 1.36)) and major bleeding (0.93 (0.78 to 1.13) and 0.79 (0.66 to 0.95)). After adjustment for baseline risk factors in treated and untreated patients, HRs (95% CI) for women (relative to men) for stroke/ SE rates were 1.3-fold higher in women (HR 1.30 (1.04 to 1.63)), and similar for major bleeding (1.13 (0.85 to 1.50)) and all-cause mortality (1.05 (0.92 to 1.19)). Antithrombotic treatment patterns in men and women were almost identical. 63.8% women and 62.9% men received AC +/- antiplatelets. Relative to no AC treatment, the reduction in stroke/ SE rates with AC treatment was greater (p= 0.01) in men (HR 0.45 (0.33 to 0.61)) than women 0.77 (0.57 to 1.03). All-cause mortality reduction with AC treatment was similar (women: 0.65 (0.54 to 0.77); men: 0.57 (0.48 to 0.68)). The risk of major bleeding when treated with AC versus no AC was 2.33 (1.41 to 3.84) in men and 1.86 (1.16 to 2.99) in women (p value= 0.53). Conclusions: Women have a higher risk of stroke/SE and the reduction in stroke/ SE events rates with AC treatment is less in women than in men.
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.isversionof10.1136/bmjopen-2016-014579
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleImpact Of Gender On Event Rates At 1 Year In Patients With Newly Diagnosed Non-Valvular Atrial Fibrillation: Contemporary Perspective From The Garfield-Af Registry
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalBmj Open
dc.contributor.departmentKardiyoloji
dc.identifier.volume7
dc.identifier.issue3
dc.description.indexWoS
dc.description.indexScopus


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster