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dc.contributor.authorMammadov, Rashad
dc.contributor.authorCinar, Goksu
dc.contributor.authorGunduz, Nuray
dc.contributor.authorGoktas, Melis
dc.contributor.authorKayhan, Handan
dc.contributor.authorTohumeken, Sehmus
dc.contributor.authorTopal, Ahmet E.
dc.contributor.authorOrujalipoor, Ilghar
dc.contributor.authorDelibasi, Tuncay
dc.contributor.authorDana, Aykutlu
dc.contributor.authorIde, Semra
dc.contributor.authorTekinay, Ayse B.
dc.contributor.authorGuler, Mustafa O.
dc.date.accessioned2019-12-10T11:21:16Z
dc.date.available2019-12-10T11:21:16Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/srep16728
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649742/
dc.identifier.urihttp://hdl.handle.net/11655/15450
dc.description.abstractSynthetic vaccines utilize viral signatures to trigger immune responses. Although the immune responses raised against the biochemical signatures of viruses are well characterized, the mechanism of how they affect immune response in the context of physical signatures is not well studied. In this work, we investigated the ability of zero- and one-dimensional self-assembled peptide nanostructures carrying unmethylated CpG motifs (signature of viral DNA) for tuning immune response. These nanostructures represent the two most common viral shapes, spheres and rods. The nanofibrous structures were found to direct immune response towards Th1 phenotype, which is responsible for acting against intracellular pathogens such as viruses, to a greater extent than nanospheres and CpG ODN alone. In addition, nanofibers exhibited enhanced uptake into dendritic cells compared to nanospheres or the ODN itself. The chemical stability of the ODN against nuclease-mediated degradation was also observed to be enhanced when complexed with the peptide nanostructures. In vivo studies showed that nanofibers promoted antigen-specific IgG production over 10-fold better than CpG ODN alone. To the best of our knowledge, this is the first report showing the modulation of the nature of an immune response through the shape of the carrier system.
dc.language.isoen
dc.relation.isversionof10.1038/srep16728
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleVirus-Like Nanostructures For Tuning Immune Response
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalScientific Reports
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume5
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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