In Vitro Activities Of Antibiotics Alone And In Combination Against Brucella Melitensis At Neutral And Acidic Phs

dc.contributor.author	Akova, M
dc.contributor.author	Gur, D
dc.contributor.author	Livermore, DM
dc.contributor.author	Kocagoz, T
dc.contributor.author	Akalin, HE
dc.date.accessioned	2019-12-10T11:14:06Z
dc.date.available	2019-12-10T11:14:06Z
dc.date.issued	1999
dc.identifier.issn	0066-4804
dc.identifier.uri	https://doi.org/10.1128/AAC.43.5.1298
dc.identifier.uri	http://hdl.handle.net/11655/15128
dc.description.abstract	Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxcycline and rifampin-doxycycline combinations.
dc.language.iso	en
dc.publisher	Amer Soc Microbiology
dc.relation.isversionof	10.1128/AAC.43.5.1298
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Microbiology
dc.subject	Pharmacology & Pharmacy
dc.title	In Vitro Activities Of Antibiotics Alone And In Combination Against Brucella Melitensis At Neutral And Acidic Phs
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.relation.journal	Antimicrobial Agents And Chemotherapy
dc.contributor.department	İç Hastalıkları
dc.identifier.volume	43
dc.identifier.issue	5
dc.identifier.startpage	1298
dc.identifier.endpage	1300
dc.description.index	WoS