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dc.contributor.authorÖzen, Seza
dc.contributor.authorBilginer, Yelda
dc.contributor.authorBesbas, Nesrin
dc.contributor.authorAyaz, Nuray Aktay
dc.contributor.authorBakkaloglu, Aysin
dc.date.accessioned2019-12-10T11:10:28Z
dc.date.available2019-12-10T11:10:28Z
dc.date.issued2010
dc.identifier.issn0340-6199
dc.identifier.urihttps://doi.org/10.1007/s00431-009-1040-y
dc.identifier.urihttp://hdl.handle.net/11655/14867
dc.description.abstractBeh double dagger et disease is the only primary vasculitis that affects both arteries and veins of any size. We present our treatment protocol in disease with vascular involvement in seven pediatric patients. All seven patients met the international criteria for the disease before the age of 16 years. Only one was a girl. The vascular involvement was as follows: Two patients had superficial vein thrombosis, two patients had atrial or ventricular thrombosis, one had arterial involvement with pulmonary aneurysms, and two had thrombosis of the venous sinuses in the central nervous system. The median duration of vascular involvement was 4 months (range 3-24 months) after the diagnosis of BD and was concomitant with diagnosis in three patients. All received colchicine and steroids. The ones with thrombosis in the venous system received additional azathioprine, whereas those with pulmonary arterial or cardiac involvement initially received cyclophosphamide for 150-180 mg/kg total dose (IV or oral) and then were switched to azathioprine for a further 6 months. All except the patient with pulmonary arterial involvement received a course of anticoagulation treatment as well. These patients have been followed up for a period of at least 18 months and so far are free of vascular relapses. One has developed a severe uveitis necessitating further therapy. In conclusion, features of vascular involvement should be carefully sought for in patients with Beh double dagger et disease. Effective management has enabled disease-free survival in the presented patients.
dc.language.isoen
dc.publisherSpringer
dc.relation.isversionof10.1007/s00431-009-1040-y
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPediatrics
dc.titleBehcet Disease: Treatment of Vascular Involvement in Children
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalEuropean Journal Of Pediatrics
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume169
dc.identifier.issue4
dc.identifier.startpage427
dc.identifier.endpage430
dc.description.indexWoS


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