dc.contributor.author | Chambers, HF | |
dc.contributor.author | Kocagöz, T | |
dc.contributor.author | Sipit, T | |
dc.contributor.author | Turner, J | |
dc.contributor.author | Hopewell, PC | |
dc.date.accessioned | 2019-12-10T10:42:54Z | |
dc.date.available | 2019-12-10T10:42:54Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 1058-4838 | |
dc.identifier.uri | https://doi.org/10.1086/513945 | |
dc.identifier.uri | http://hdl.handle.net/11655/14258 | |
dc.description.abstract | Some beta-lactam antibiotics are active in vitro against Mycobacterium tuberculosis. There are anecdotal reports of successful treatment of tuberculosis caused by multiple-drug-resistant strains of M. tuberculosis with regimens that included amoxicillin/clavulanate. Reduction of M. tuberculosis in the sputum of patients with pulmonary tuberculosis during administration of amoxicillin/clavulanate was measured by a quantitative culture method to determine the activity in vivo. Patients were randomized to receive isoniazid, ofloxacin, or amoxicillin/clavulanate for 7 days, Isoniazid was the most effective agent, reducing M. tuberculosis after 2 days at a mean rate (+/- standard deviation) of 0.60 +/- 0.30 log(10) cfu/ml per day, compared with 0.32 +/- 0.05 and 0.34 +/- 0.03 for ofloxacin and amoxicillin/clavulanate, respectively. The early bactericidal activity of amoxicillin/clavulanate was comparable to that reported for antituberculous agents other than isoniazid, Further studies of beta-lactam antibiotics with in vitro activity against M. tuberculosis are warranted to define their role in treatment of tuberculosis. | |
dc.language.iso | en | |
dc.publisher | Univ Chicago Press | |
dc.relation.isversionof | 10.1086/513945 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Immunology | |
dc.subject | Infectious Diseases | |
dc.subject | Microbiology | |
dc.title | Activity of Amoxicillin/Clavulanate in Patients with Tuberculosis | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Clinical Infectious Diseases | |
dc.contributor.department | Çocuk Sağlığı ve Hastalıkları | |
dc.identifier.volume | 26 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 874 | |
dc.identifier.endpage | 877 | |
dc.description.index | WoS | |