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dc.contributor.authorBüyükpamukçu, M.
dc.contributor.authorSarialioğlu, F.
dc.contributor.authorAkyüz, C.
dc.contributor.authorCevik, N.
dc.date.accessioned2019-12-10T10:35:21Z
dc.date.available2019-12-10T10:35:21Z
dc.date.issued1987
dc.identifier.issn0007-0920
dc.identifier.urihttps://doi.org/
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001901/
dc.identifier.urihttp://hdl.handle.net/11655/13865
dc.description.abstractFrom January 1983 to December 1986 seventy-six previously untreated children with non-Hodgkin's lymphoma (NHL) were treated by combination chemotherapy. Burkitt's lymphoma patients were ineligible. The treatment regimens include intermittent chemotherapy and for non-localized patients, prophylactic central nervous system chemotherapy. Intrathoracic non-Hodgkin's lymphoma patients also had cranial prophylactic radiotherapy. Sixty-six patients (86.8%) achieved complete remission. Two year failure-free survival rate was 82.1% for localized (stage I and II) NHL and 53.3% for non-localized (stage III and IV) NHL patients. Failure-free survival did not differ significantly for the two major histologic diagnoses, but two year survival rate was lower in diffuse poorly differentiated lymphoblastic than undifferentiated non-Burkitt's lymphoma (50% versus 66.8% respectively). Failure-free survival rate was 53.7% in mediastinal disease and, 73.2% in abdominal disease at 24 months. Relapse rate was higher in mediastinal cases (46.1%) than primary abdominal cases (24.3%) at 24 months. Eleven (13.5%) died of treatment related sepsis. Although the overall survival rate was 72.4% at 2 years we need novel or more intensive programmes for mediastinal and non-localized disease.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCombined Chemotherapy In 76 Children With Non-Hodgkin'S Lymphoma Excluding Burkitt'S Lymphoma.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalBritish Journal of Cancer
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları
dc.identifier.volume56
dc.identifier.issue5
dc.identifier.startpage625
dc.identifier.endpage628
dc.description.indexPubMed
dc.description.indexWoS


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