Ara
Toplam kayıt 770, listelenen: 21-30
Kolşisinin Pyrin ve Pyrin ile Ilişkili Proteinler Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2012)
MEFV which encodes pyrin, causes familial Mediterranean fever (FMF), the most common auto-inflammatory disease. Pyrin is believed to be a regulator of inflammation, though the nature of this regulatory activity remains to ...
Lizozomal Depo Hastalığı Olan Gaucher Hastalığında Otofaji Mekanizmasının Moleküler Düzeyde İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)
Lysosomes are the most important degradation organelles of the cell. The functions of the lysosomes depend upon the harmonious coordination between the lysosomal hydrolases and the lysosomal membrane proteins existing in ...
New Approach to Unsupervised Based Classification on Microarray Data
(Sağlık Bilimleri Enstitüsü, 2013)
Genetic studies have been an important part of medical researches in recent years. These studies have become essential for the development of personalized treatment options and discovery of new drugs. The majority of these ...
Nörofibromatozis Tip 1 ile İlişkili Tümörlerde C-X-C Kemokin Reseptör Tip 4 Gen İfade Düzeyinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2013)
Neurofibromatosis type 1 (NF1) is a common genetic disorder that affects skin
and nervous system that is inherited in autosomal dominant trait. It occurs due to the
mutations in NF1 gene. The most common Schwann cell ...
Metakromatik Lökodistrofi: Üç Arilsülfataz A Mutasyonunun (P.307Glu→Lys, P.318Trp→Cys Ve C.1165G Delesyonu) Arilsülfataz A Aktivitesi ve Arilsülfataz A Proteini Üzerine Etkisinin Tanımlanması
(Tıp Fakültesi, 2013)
Metachromatic leukodystrophy (MLD) is an autosomal recessively inherited sphingolipid storage disease that occurs as a result of a lack of lysosomal enzyme Arylsulfatase A (ASA) or its activator protein. In this study, two ...
Otoimmün Hepatitli Hastalarda Hepatik Fibrozis Düzeyinin Değerlendirilmesinde Elf Testi ile Karaciğer Biyopsisinin Tanısal Değerlerinin Karşılaştırılması
(Tıp Fakültesi, 2013)
Autoimmune hepatitis is a chronic inlammatory disease characterized by hepatomegaly, presence of autoantibodies and polyclonal hypergammaglobulinemia. As a chronic liver disease, fibrosis is one of the complications of ...
Soğuk-Hareketsizlik Stresinin Farelerin Periferal Kanındaki Yardımcı T Hücre Yanıtına Etkisi
(Sağlık Bilimleri Enstitüsü, 2014)
Stress brings out a non-spesific response, modulating the immune
system so blamed in pathophysiology of various diseases. Helper T (Th) lymphocytes have a
central role both in acquired immune system response and in its ...
Polikistik Over Sendromunun Patogenezinde Progranulin ve Tnf-Alfa Nın Rolü
(Tıp Fakültesi, 2013)
Polycystic ovary syndrome (PCOS) is chacterized by menstrual irregularities, hirsutism, acne and obesity. Chronic and subclinic inflammation, insulin resistance are the basic pathological mechanisms of PCOS. Tumor necrosis ...
Kistik Fibrozisli Hastalarda Anaerop Bakterilerin Rolünün Araştırılması
(Tıp Fakültesi, 2012)
Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus
influenzae and Burkholderia cepacia complex are the most frequently
isolated microorganisms from respiratory tract samples of the cystic
fibrosis patients. ...
Serotonin Geri Emilim Blokörlerinin Hemoreolojik Parametreler Üzerine Etkileri
(Sağlık Bilimleri Enstitüsü, 2013)
Serotonin reuptake inhibitors (SSRI) are widely prescribed drugs for the therapy of major depression. SSRIs both effect on the synaptic level and increase blood serotonin level acutely. There are no detailed studies focusing ...