Gestasyonel Diabetes Mellitus Gelişiminde Mody Gen Polimorfizmlerinin Yeri Nedir?

Abstract

Aim: This study aims to investigate the association between MODY genes and gestational diabetes mellitus (GDM) to understand the pathogenesis and thereby to provide predictive markers for GDM. Methods: Ninety-three patients with the diagnosis of gestational diabetes according to the diagnostic criteria of 2011 ADA and 90 pregnant normal subjects were included in the study. Patients with T1DM or T2DM diagnosis before pregnancy or with organ failure were excluded. Peripheric blood samples were obtained from all the participants. Samples were investigated for the genetic polymorphisms of IGF2BP2 (rs1470579), GCK (rs1799884), HNF1A (rs1169288) and HNF4A (rs2144908) genes. Results: High-risk allelle of HNF4A (rs2144908) gene polymorphism is statistically significantly associated with GDM (p=0.038). HNF1A (rs1169288), IGF2BP2 (rs1470579) and GCK (rs1799884) gene polymorphisms have no relationship with GDM, though high-risk allelles of IGF2BP2 (rs1470579) and GCK (rs1799884) gene polymorphisms were more frequent in study group. Besides, as the number of the high-risk allelles of the four genes increasing, the risk of GDM increased as well (p=0.012). Conclusion: We concluded that the risk of GDM is related to the additive effect of these four genes (IGF2BP2 (rs1470579), GCK (rs1799884), HNF1A (rs1169288) and HNF4A (rs2144908) ) rather than a single gene effect which is introduced to the literature for the first time, here.