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Toplam kayıt 41, listelenen: 21-30
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)
One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ...
Sağlıklı İnsan Uyarılmış Pluripotent Kök Hücrelerinden Kortikal Nöron Elde Edilmesi
(Sağlık Bilimleri Enstitüsü, 2023)
Induced pluripotent stem cells (iPSC) are a unique resource for personalized treatment, disease modeling and drug trials. Target tissue and organ formation can be achieved with various transcription factors or small molecules ...
Sağlıklı İnsan Uyarılmış Pluripotent Kök Hücrelerinden (uPKH’lerden) NGN2, LHX3 ve ISL1 Üçlü Kasedi Kullanarak Motor Nöron Eldesi
(Sağlık Bilimleri Enstitüsü, 2023)
Neurodegenerative diseases are progressive and fatal diseases that reduce the standard of living of individuals and cause significant functional losses. Amyotropic lateral sclerosis (ALS) is a disease caused by motor neurone ...
Baş Boyun Kanserli Hastaların Tükürük Örneklerinden İzole Edilen Eksozom ve Bakterilerin, Sağlıklı Kemik İliği Mezenkimal Kök Hücreler Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-01-25)
Recently, in the development of head and neck cancers, the components, which are responsible for the interaction between cells and surrounding healthy tissues, in the tumor microenvironment have become a burgeoning area. ...
Podosit Hasar Modelinde İndüklenmiş Mezenkimal Kök Hücrelerinin Etkisi
(Sağlık Bilimleri Enstitüsü, 2023-02-08)
Sahan, OB., The Effect of İnduced Mesenchymal Stem Cells On Podocyte Injury Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, Ankara,2023. Self-renewal, ...
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)
Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ...
Allojenik Mezenkimal Kök Hücreler ve Mikroakışkan Sistemle Vücut Dışında Testisteki Spermatogonyal Kök Hücre Mikroçevresinin Devamlılığının Sağlanması
(Sağlık Bilimleri Enstitüsü, 2023)
Chemoradiotherapeutics used in childhood cancers result in permenant infertility in half of male patients. Bone marrow derived mesenchymal stem cells (BMMSC) share some of their secretomes and their embryonic origin with ...
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)
Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ...
Kemik İliği Mezenkimal Kök Hücrelerinde p53 Yolağı Regülasyonunda PKNOX2 ve Etkileşimlerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023)
Mesenchymal Stem Cells (MSC) are good platforms to study in-vitro molecular mechanisms. Like all cells, MSCs detect and respond to various stimuli with molecular signal mechanisms. p53 signal pathway is a well-known molecular ...
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)
RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ...