Otoimmün Hepatitte Serum Vitamin-D Düzeyi ve Karaciğer Histolojisi ile İlişkisinin Araştırılması

Abstract

This study evaluated the Vitamin D levels (Vit-D) of the serum samples which were obtained from patients diagnosed with autoimmune hepatitis (AIH) between November 2010 and September 2013, at the Hacettepe University Department of Gastroenterology. The patients data were obtained from the hospital electronic medical record system (Neksus). A total of 72 subjects, including 43 patients with AIH diagnoses and 29 control group subjects were included in the study. There was no statistically significant difference in the mean age and gender between groups. The mean Vit-D levels in AIH patients were significantly lower than the control group (16.5± 9.9 v.s. 29.3±15.6, p=0.0001). When Vit-D levels <30 was taken as deficiency, Vit-D levels in AIH patients was once more found to be significantly lower when compared to the control group (%86 v.s. %52, p=0.002). When AIH patients were grouped with respect to having early or late stage fibrosis, there were no statistically significant differences in age, gender and biochemical parameters. However, mean Vit-D levels were significantly lower in patients with high fibrosis score, when compared to patients with low fibrosis score (21.8 ± 10.3 v.s 11.0± 5.8, p=0.001). Also, when Vit-D levels <30 was taken as deficiency, patients with advanced stage fibrosis were found to have lower levels when compared to patients with early stage fibrosis (%100 v.s %73, p=0.01). In conclusion, Vit-D levels are significantly lower in patients with AIH. Furthermore, in these patients, there is a negative correlation between Vit-D levels and histological stage.