Opere Edilebilir Meme Kanserli Hastalarda Inflamatuvar Markerların Prognoz Üzerine Etkisinin Incelenmesi

Abstract

The aim of this study is to investigate the effect of inflammatory markers on prognosis among patients with operable breast cancer. This study was conducted on patients followed up between December 2009 and December 2012, at Division of Medical Oncology, Department of Internal Medicine, Hacettepe University Medical School. A total of 704 patients with stages I to III breast cancer whose inflammatory markers were ordered at the time of diagnosis were included the study. Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, ferritin, β2 microglobulin, and lactate dehydrogenase (LDH) levels were evaluated as inflammatory markers. The median age at diagnosis was 50 (25-92). Of the patients 42.8 % were premenopausal and 48.2 % were postmenopausal. Invasive ductal carcinoma was the most common histology (76.5 %). Serum ferritin, LDH, β2 microglobulin, ESR, and CRP were higher than the normal values in 1.0 %, 4.3 %, 9.5 %, 32.4 % and 36.4 % of the patients, respectively. Serum albumin levels were lower than the normal values in 1.7 % of the patients. The median follow-up period of the patients was 22 months (3-227). During this follow-up, metastatic disease developed in 31 patients (4.4 %) and 11 patients (1.56 %) died due to disease progression. Two year overall survival and disease free survival rates were not statistically different among patients with normal values and abnormal values with respect to albumin, ferritin, LDH, β2 microglobulin, CRP, and ESR. v Our study is the first study that investigated the effect of inflammatory markers on the prognosis of operable breast cancer patients. We showed that inflammatory markers such as ESR, CRP, ferritin, B2 microglobulin, albumin and LDH have no effect on prognosis. We suppose that the following factors might have an influence on the results of our study. As the follow up time is not long enough, the small number of events makes it hard to make a precise conclusion. All the patients had early disease that could not evoke the inflammatory process. Another reason that might have affected our results is that blood sampling time after surgery is not uniform. In conclusion, we believe that further studies with a longer follow-up and enough event number should be conducted.