Hodgkin Lenfoma; Beş Yaş Altındaki 102 Olgunun Retrospektif Analizi

Abstract

Aim: To evaluate the clinical characteristics, treatment regimens, and outcome of the patients with Hodgkin lymphoma under five years old. Patients and methods: 102 patients diagnosed with Hodgkin lymphoma between 1972 and 2013 were retrospectively evaluated. All patients were treated with chemotherapy with or without radiotherapy. Chemotherapeutic regimens included COPP derivatives (cyclophosphamide or mustargen + vincristine + prednisolone + procarbazine), ABVD (Adriamycin + Bleomycin + Dacarbazine + Vinblastine), and alternated ABVD/COPP). Staging was done according to Ann Arbor classification system and histopathologic examination was done according to Rye system. Mean and median values were used for the demographic characteristics. Kaplan-Meier survival curves were used for survival analysis. The patient groups were compared in terms of survival duration using a log-rank test. Results: There were 81 males and 21 females with a median age of 4 years (2 to 4.9). 23 patients had B symptoms and 15 patients had bulky disease. Stage distributions were 45, 32, 16, and 9 patients in stage I, II, III, and IV, respectively. Histopathologic subtypes were mixed cellularity, nodular sclerosis, lymphocytic predominance, lymphocytic depletion, noduler lymphocyte predominant, unclassified in 63, 12, 11, 3, 2, 11 patients, respectively. Overall, and event-free survival rates were 89.7 and 74.8% with a median follow-up time of 13 years. OS rates were significantly different according to stage (p=0.008). Although there were no statistically significant difference, Bulky disease and B symptoms positivity were associated with poor prognosis. OS rates were 77 and 91.8 % in patients with and without bulky disaese, respectively (p=0.08). These rates were 77.8 % and 92.9% according to B symptom positivity (p=0.07).