Deri Eki Tümörlerinin Histopatolojik Açıdan Değerlendirilmesi ve Wnt Yolağı ile İlişkisinin Araştırılması

Abstract

The aim of this study is histopathological evaluation and classification of cutaneous adnexal tumors, and identification of the relationship between these tumors and Wnt/beta-katenin pathway by immunohistochemistry. One hundred thirty nine biopsies which had the diagnoses of any cutaneous adnexal tumor between January 2000-July 2011 at Department of Pathology (Hacettepe University, Faculty of Medicine) were reevaluated and 35 cases with a new diagnosis of BCC, SCC, metastatic carcinoma, malignant epithelial neoplasm and non-tumoral lesion were excluded. The remaining 104 cases are given specific diagnoses and classified into 3 groups as lesions with predominant eccrine-apocrine, predominant follicular and multilineage differentiation. Beta-catenin expressions of 82 tumors suitable for staining were evaluated (score 0-5). Among all, 73,6% of follicular, 67,27% of eccrine-apocrine and 62,5% of multilineage tumors had a score 4 or 5. Spiradenoma, cylindroma and spiradenocylindroma make up 85,7 % of tumors with score 5. We concluded that; 1) cutaneous adnexal tumors can be diagnosed at ease by experience, 2) SCCs and metastatic carcinomas to the skin are often confused with malignant cutaneous adnexal tumors, 3) follicular cutaneous adnexal tumors are confused with BCCs, 4) Wnt / beta-catenin pathway dysregulation can have a role in pathogenesis of spiradenoma, cylindroma and spiradenocylindroma. Key words: cutaneous adnexal tumor, classification, beta-catenin, immünohistochemistry.