Kaposi Sarkomlarının Histopatolojik Açıdan Değerlendirilmesi, Emmprin Cd147 Protein Ekspresyonunun Tümör Biyolojik Davranışı ile İlişkisinin Araştırılması

Abstract

Kaposi sarcoma (KS) is a vascular tumour of low grade malignant potential caused by an oncogenic-herpesvirus, Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV 8). KS has 4 clinical types defined according to epidemiological and clinical features; classical, endemic (African type), epidemic (AIDS-related) and iatrogenic (transplantation-related) KS. Classical KS (CKS) is mostly seen in old males with Jewish, East European and Mediterranean origin. This is the most common type in our country. Lesions are mostly asymptomatic and present as brown-red, purple or black patch, plaque and nodules. Most common complications are chronic venous stasis and lymphedema. 79 KS cases, diagnosed between January 1982 - September 2013 at the Department of Pathology Hacettepe University Faculty of Medicine, were examined in terms of clinical and histopathological features. The expression of Emmprin / CD147, HHV-8 / LNA, CD31 and CD117 proteins was evaluated in these examples using immunohistochemical techniques. Emmprin / CD147 protein plays a key role in viral pathogenesis, cell migration and in the development of chemoresistance. Overexpression of this protein is thought to be evidence in favor of progression. We demonstrated relationship between recurrence, histopathological parameters, disease stage and CD147 expression in this study. CD147 overexpression was found to be associated with advanced stage. Significant correlation between nodular growth pattern, presence of solid fibrosarcomatous areas and the expression of CD147 was also seen. Findings in our study can be important for targeted therapies in KS patients.