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dc.contributor.advisorİrkeç, Murat
dc.contributor.advisorKocabeyoğlu, Sibel
dc.contributor.authorGençoğlu, Aysun
dc.date.accessioned2019-05-10T13:37:47Z
dc.date.issued2018-11
dc.date.submitted2018-11-08
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dc.identifier.urihttp://hdl.handle.net/11655/7152
dc.description.abstractABSTRACT Aysun G. Evaluation of Serum Sirtuin and Adiponectin Levels in patients with Primary Open-Angle Glaucoma and Exfoliative Glaucoma, Ankara, 2018. The aim of this study is to compare the serum sirtuin 1 (SIRT1) and adiponectin levels in patients with primary open-angle glaucoma (POAG) and exfoliative glaucoma (EG) with healthy control subjects over 50 years of age. Blood samples were collected from 40 patients with POAG, 38 patients with EG and 40 individuals over 50 years of age with no systemic or ocular disease. Serum SIRT1 and adiponectin was estimated by Enzyme Linked Immunosorbent Assay (ELISA). In patients with POAG (0.731 ng / ml), a significant (p = 0.004) decrease in SIRT1 concentration was observed compared to controls (1.423 ng / ml). Statistically significant difference was not found in patients with EG (1.155 ng / ml) compared to controls and patients with POAG (p=0,345, p=0,325). There was no statistically significant difference in serum adiponectin levels between the 3 groups (p=0.590). There was no statistically significant difference found to the distribution of SIRT1 levels by sex (p=0.343). Serum adiponectin levels were significantly (p=0.002) higher in women. In conclusion; in this study, serum SIRT1 level was found to be lower in patients with POAG than control subjects. There was no statistically significant difference in adiponectin levels between the 3 groups. Our results suggest that SIRT1 may play a protective role in POAG. Key words: Primary open angle glaucoma, exfoliative glaucoma, sirtuin, adiponectin, neurodegenerationtr_TR
dc.description.sponsorshipTHD-2018-16906tr_TR
dc.description.tableofcontentsİÇİNDEKİLER Sayfa No: TEŞEKKÜR ii ÖZET iii ABSTRACT iv İÇİNDEKİLER v KISALTMALAR viii ŞEKİLLER DİZİNİ x GRAFİKLER DİZİNİ xi TABLOLAR DİZİNİ xii 1. GİRİŞ VE AMAÇ 1 2. GENEL BİLGİLER 3 2.1. GLOKOM 3 2.1.1. Primer Açık Açılı Glokom 3 2.1.1.1. Tanım 3 2.1.1.2. Risk Faktörleri 4 2.1.1.3. Patofizyoloji 4 2.1.2. Eksfoliasyon Sendromu 7 2.1.2.1. Tanım 7 2.1.2.2. Patogenez 7 2.1.2.3. Klinik Bulgular 8 2.1.3. Eksfoliasyon Glokomu 8 2.1.3.1. Tanım 8 2.1.3.2. EG ve Sistemik Hastalıklar 8 2.2. SİRTUİN 9 2.2.1. Tanım 9 2.2.2. SIRT1’in Fizyolojik Rolleri 11 2.2.2.1. Obezite ile İlişkili Metabolik Hastalıklar 11 2.2.2.2. Kanser 11 2.2.2.3. Hücresel Yaşlanma 11 2.2.2.4. Kardiyak Yaşlanma ve Stres 12 2.2.2.5. Nörodejenerasyon 12 2.2.2.6. İnflamasyon 12 2.2.2.7. Anjiogenez 12 2.2.3. Gözdeki SIRT1'in Gelişimsel Rolleri 13 2.2.4. SIRT1’in Oküler Dağılımı 13 2.2.5. SIRT1 ve Göz Hastalıkları 14 2.2.5.1. SIRT1 ve Katarakt 14 2.2.5.2. SIRT1 ve Yaşa Bağlı Makula Dejenerasyonu 15 2.2.5.3. SIRT ve Diyabetik Retinopati 16 2.2.5.4. SIRT1 ve Optik Nöropati 16 2.2.5.5. SIRT1 ve Glokom 17 2.2.6. SIRT1 ve Sistemik Hastalıklar 17 2.3. ADİPONEKTİN 17 2.3.1. Tanım 17 2.3.2. Adiponektİn Reseptörleri ve Adiponektin Sinyali 18 2.3.3. Adiponektin ve Göz Hastalıkları 19 2.3.3.1. Adiponektin ve Yaşa Bağlı Makula Dejenerasyonu 19 2.3.3.2. Adiponektin ve Diyabetik Retinopati 20 2.3.4. Adiponektinin Nöroprotektif Özellikleri 20 3. GEREÇ VE YÖNTEM 21 3.1. ARAŞTIRMAYA DAHİL OLMA KRİTERLERİ 21 3.2. ARAŞTIRMADAN DIŞLANMA KRİTERLERİ 23 3.3. KAN ÖRNEKLENMESİ VE SAKLANMASI 23 3.4. PLAZMA SIRT1 KONSANTRASYONLARININ ÖLÇÜLMESİ 23 3.4.1. Numunelerin hazırlanması 23 3.4.2. Standartların ve diğer reaktiflerin hazırlanması 23 3.4.3. Deneyin yapılışı 23 3.5. PLAZMA ADİPONEKTİN KONSANTRASYONLARININ ÖLÇÜLMESİ 24 3.5.1. Numunelerin Hazırlanması 24 3.5.2. Standartların ve Diğer Reaktiflerin Hazırlanması 24 3.5.3. Deneyin Yapılışı 24 3.6. İSTATİSTİKSEL ANALİZ 25 4. BULGULAR 26 5. TARTIŞMA 30 6. SONUÇLAR 37 7. KAYNAKLAR 38tr_TR
dc.language.isoturtr_TR
dc.publisherTıp Fakültesitr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectPrimer açık açılı glokomtr_TR
dc.subjectSirtuin
dc.subjectEksfoliatif glokom
dc.subjectAdiponektin
dc.subjectNörodejenerasyon
dc.titlePrimer Açık-Açılı Glokom ve Eksfoliatif Glokomda Serum Sirtüin ve Adiponektin Düzeylerinin Değerlendirilmesitr_TR
dc.typeinfo:eu-repo/semantics/doctoralThesistr_TR
dc.description.ozetÖZET Aysun G. Primer Açık-Açılı Glokom ve Eksfoliatif Glokomda Serum Sirtuin ve Adiponektin Düzeylerinin Değerlendirilmesi, Ankara, 2018. Bu çalışmanın amacı; primer açık açılı glokom (PAAG) ve eksfoliatif glokomda (EG) serum sirtüin 1 (SIRT1) ve adiponektin düzeyini 50 yaş üstü sağlıklı kontrollerle kıyaslamaktır. Bu amaçla kliniğimize başvurmuş, 40 PAAG hastası, 38 EG hastası ve 40 sistemik ve/veya oküler hastalığı bulunmayan 50 yaş üstü bireyden kan örnekleri toplandı. Serum SIRT1 ve adiponektin düzeyleri Enzyme Linked Immunosorbent Assay (ELİSA) yöntemi ile tespit edildi. PAAG’lı hastalarda (0,731 ng / ml) kontrollere (1,423 ng / ml) kıyasla SIRT1 konsantrasyonunda anlamlı (p=0,004) bir düşüş gözlendi. EG’li hastalarda (1,155 ng / ml) kontrollere ve PAAG’lı hastalara göre SIRT1 düzeyinde istatistiksel olarak anlamlı fark (p=0,345, p=0,325) saptanmadı. Serum adiponektin düzeyinde 3 grup arasında istatistiksel olarak anlamlı fark (p=0,590) bulunmadı. Cinsiyete göre değerlendirme yapıldığında, SIRT1 dağılımında istatistiksel olarak anlamlı fark (p=0,343) saptanmadı. Kadınlarda serum adiponektin düzeyleri istatistiksel olarak anlamlı (p=0,002) bir şekilde yüksek çıkmıştır. Sonuç olarak çalışmamızda PAAG’de kontrol grubuna göre daha düşük SIRT1 seviyeleri görülmüştür. Adiponektin düzeylerinde ise 3 grup arasında istatistiksel olarak anlamlı fark saptanmamıştır. Sonuçlarımız, SIRT1’in PAAG’de koruyucu bir rol oynayabileceğini düşündürmektedir. Anahtar Kelimeler: Primer açık açılı glokom, eksfoliatif glokom, sirtuin, adiponektin, nörodejenerasyontr_TR
dc.contributor.departmentGöz Hastalıklarıtr_TR
dc.contributor.authorID10244462tr_TR
dc.embargo.termsAcik erisimtr_TR
dc.embargo.lift2019-05-10T13:37:47Z
dc.subtypemedicineThesis


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