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Inhibition of Serum and Glucocortıcoıd Inducible Kinase 1 (Sgk1) in Triple Negative Breast Cancer
(Kanser Enstitüsü, 2018-07-18)
Glucocorticoid receptor overexpression leads to poor prognosis in breast cancer, particularly in triple negative phenotype. This poor prognosis has been shown to be due to the activation of SGK1 (serum and glucocorticoid ...
Meme Kanseri Hücrelerinde Pı-103 Inhibitörünün Aktive Reseptör Tirozin Kinaz Ekspresyonuna Etkisinin Incelenmesi
(Kanser Enstitüsü, 2014)
Oncogenic activation of PI3K/Akt/mTOR signaling pathway is frequently seen in breast cancer. Inhibition of signaling pathway by PI3K inhibitors, tyrosine kinase inhibitors and/or monoclonal antibodies causes increase in ...
Meme Kanseri Hücrelerinde Kostimülatör B7 Ailesi Ligandlarının Ekspresyonu ve Yardımcı T Hücre Yanıtları Üzerine Etkisi
(Kanser Enstitüsü, 2013)
B7 ligands are the most critical costimulatory molecules that regulate T cell responses. Although these molecules are mainly expressed on professional antigen presenting cells, they may also be expressed on tumor cells. ...