Ratlarda İntraartiküler İbuprofen Enjeksiyonunun Kartilaj ve Sinoviya Üzerine Etkisi

Abstract

Postoperative poor pain control is an important cause of late discharge and rehabilitation after arthroscopy. In treatment, Intraarticular drug injections are preferred methods because of their minimal systemic side effects. For this purpose, showing the cytotoxic effects of local anesthetics used on cartilage tissue has been restricted to the use of these drugs. In recent years, the intra-articular application of non-steroidal anti-inflammatory drugs has been discussed. However, there is no study investigating the histopathological effects of ibuprofen in healthy cartilage tissue. Therefore, we aimed to study the histopathological effects of ibuprofen, which come into question with the use of intraarticular use. The right lower extremities of the 20 rats included in the study were used for treatment group and the left lower extremities for the control group. 0.25mg/0.25 ml of ibuprofen into left knee and 0.25 ml of 0.9% SF were injected intraarticularly. Five randomized groups were sacrificed following 1, 2, 7, 14, and 21 days, both knee joints were dissected. They were stained with hematoxylin-eosin and examined by light microscopy 4 weeks after decalcification. Signs of inflammation in the knee joint, synovium and peripheral areas; congestion, edema, neutrophil infiltration, chronic inflammation, synovial hyperplasia, subintimal fibrosis were evaluated histopathologically. Bonferroni-corrected Mann Whitney U test and Wilcoxon Sign Rank test was used for intergroup and intra-group comparisons, and p<0.010 and p<0,0025 was considered statistically significant respectively. Synovial hyperplasia and subintimal fibrosis scores were 0 (zero) in all samples. Although congestion, edema and neutrophil infiltration were more common in the ibuprofen group on days 1 and 2, no statistically significant difference was found. The groups were similar in terms of chronic inflammation findings. There are studies that examine the histopathological effects of NSAI drugs on joints and exhibit that it reduces inflammation in rat models. Intraarticular tenoxicam injection has also been shown to contribute to analgesia in patients with osteoarthritis. In our study, although intraarticular ibuprofen injection seems safe, more detailed studies are needed to evaluate both histopathological and analgesic effects for more accurate results.